S80039 |
BAY 80-6946 (Copanlisib) |
| MedMol | 98% |
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- 产品描述： Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity
- 靶点： PI3Kα：0.5 nM (IC50)；PI3Kβ：3.7 nM (IC50)；PI3Kδ：0.7 nM (IC50)；PI3Kγ：6.4 nM (IC50)；mTOR：45 nM (IC50)
- 体内研究： Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model
- 参考文献：
1. Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30.
- 溶解性： 1M HCl : 100 mg/mL (208.11 mM; Need ultrasonic)
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.081 ml 10.405 ml 20.811 ml 5 mM 0.416 ml 2.081 ml 4.162 ml 10 mM 0.208 ml 1.041 ml 2.081 ml 50 mM 0.042 ml 0.208 ml 0.416 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
