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S80074

Zafirlukast

MedMol 98%
  • 英文名:
  • Zafirlukast
  • 别名:
  • 扎鲁司特;扎鲁斯特;[3-[2-甲氧基-4-[(2-甲苯基)磺酰胺基甲酰基]苄基]-1-甲基-吲哚-5-基]氨基甲酸环戊酯;[3-[[2-甲氧基-4-[[[(2-甲基苯基)磺酰基]氨基]羰基]苯基]甲基]-1-甲基-1H-吲哚-5-基]氨基甲酸环戊基酯;扎夫司特;ZAFIRLUCAST;印度 THYKN;ZAFIRLUKAST;cyclopentyl n-[3-{[2-methoxy-4-[(2-
  • CAS号:
  • 107753-78-6
  • 分子式:
  • C31H33N3O6S
  • 分子量:
  • 575.675
  • 核磁/质谱:
货号产品规格市场价(RMB)您的折扣价(RMB)库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
S80074-50mg 98% ¥600.00元 ¥510.00元 4 0 0 0 EA 加入购物车
S80074-100mg 98% ¥1060.00元 ¥901.00元 2 0 0 0 EA 加入购物车
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产品介绍

参考文献(1篇)

质检证书(COA)

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  • 提示:详情请下载说明书。
  • 产品描述: Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
  • 靶点: LTD4
  • 体内研究: Zafirlukast is a peptidyl leukotriene antagonist and inhibitor of LTD4. After 13 weeks of exposure, the yield of lung tumors is significantly decreased by both dose levels of Zafirlukast (270 and 540 mg/kg), the high dose of Zileuton (1200 mg/kg), and the combinations containing 600 mg/kg Zileuton with either Zafirlukast or MK-866. The efficacy of the combination containing Zileuton and Zafirlukast to prevent lung tumors is not significantly different from the efficacy of either inhibitor administered alone. Although when administered alone at the dose level in their combination, neither Zileuton or MK-886 prevents lung tumors; the combination containing them does significantly prevent tumors. In contrast, the combination containing Zafirlukast and MK-886 does not reduce the yield of tumors, whereas Zafirlukast administered alone does significantly reduce the yield of tumors
  • 参考文献:
    1. Finnerty JP, et al. Role of leukotrienes in exercise-induced asthma. Inhibitory effect of ICI 204219, a potent leukotriene D4 receptor antagonist. Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):746-9. 2. Gunning WT, et al. Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice. Cancer Res. 2002 Aug 1;62(15):4199-201. 3. Lei C, et al. Zafirlukast attenuates advanced glycation end-products (AGEs)-induced degradation of articular extracellular matrix (ECM). Int Immunopharmacol. 2019;68:68-73.
  • 溶解性: DMSO  :  100  mg/mL  (173.71  mM;  Need  ultrasonic)
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 1.737 ml 8.685 ml 17.371 ml
    5 mM 0.347 ml 1.737 ml 3.474 ml
    10 mM 0.174 ml 0.869 ml 1.737 ml
    50 mM 0.035 ml 0.174 ml 0.347 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)


  • =
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