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S80109

Mosapride

MedMol 98%
  • 英文名:
  • 4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide
  • 别名:
  • 莫沙必利;4-氨基-5-氯-2-乙氧基-N-[[4-(4-氟苄基)-2-吗啉基]甲基]苯甲酰胺/莫沙必利;莫沙比利;MOSAPRIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE;4-AMINO-5
  • CAS号:
  • 112885-41-3
  • 分子式:
  • C21H25ClFN3O3
  • 分子量:
  • 421.893
  • MDL:
  • MFCD00867430
  • 核磁/质谱:
货号产品规格市场价(RMB)您的折扣价(RMB)库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
S80109-10mg 98% ¥300.00元 ¥204.00元 9 0 0 0 EA 加入购物车
S80109-50mg 98% ¥800.00元 ¥544.00元 预计交期:2-3天 0 0 0 EA 加入购物车
S80109-250mg 98% ¥1800.00元 ¥1224.00元 1 0 0 0 EA 加入购物车
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  • 产品描述: Mosapride是胃动力药,是选择性的5HT4激动剂
  • 靶点: 5HT4
  • 体外研究: Mosapride facilitates acetylcholine release from the enteric cholinergic neurons. It does not block K+ channels or D2 dopaminergic receptors. Mosapride is a selective 5-HT4 receptor agonist with no affinity for 5-HT1, 5-HT2, adrenalineα1, adrenalineα2 or dopamine D2 receptors
  • 体内研究: Mosapride augmented lower gastrointestinal motility in animal models and in patients with lower gastrointestinal disorders. It enhanced defecation responses in animal models. In human, after oral administration of single doses of mosapride 5-40 mg, peak mosapride concentrations (Cmax) were reached after about 1 hour. Both the Cmax and area under the concentration-time curve from time zero to infinity (AUC∞) increased in a dose-proportional manner. There were no significant differences in the pharmacokinetic profiles of mosapride administered as single or multiple doses. Mosapride is excreted in the urine and faeces. It is primarily metabolized in the liver by cytochrome P450 3A4 to the active metabolite, a des-4-fluorobenzyl compound
  • 动物实验: Animal Models: Male Hartley guinea pigs Dosages: 3, 10 and 30 mg/kg Administration: i.g.
  • 参考文献:
    1. Inui A, et al. Effects of mosapride citrate, a 5-HT4 receptor agonist, on colonic motility in conscious guinea pigs. Jpn J Pharmacol. 2002, 90(4):313-20. 2. Liu Z, et al. Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients. Mov Disord. 2005, 20(6):680-6. 3. Monique P. Curran, et al. Mosapride. Drugs (2008) 68: 981.
  • 溶解性: soluble  in  DMSO
  • 保存条件: -20℃
  • 备注: Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. Target: 5HT4 Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. The major active metabolite of mosapride, known as M1, additionally acts as a 5HT3 antagonist, which accelerates gastric emptying throughout the whole of the gastrointestinal tract in humans, and is used for the treatment of gastritis, gastro-oesophageal reflux disease, functional dyspepsia and irritable bowel syndrome. It is recommended to be
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.37 ml 11.851 ml 23.703 ml
    5 mM 0.474 ml 2.37 ml 4.741 ml
    10 mM 0.237 ml 1.185 ml 2.37 ml
    50 mM 0.047 ml 0.237 ml 0.474 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)


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