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• 产品描述： Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.

• 靶点： Apoptosis;HDAC

• 体内研究： In SCID mice models, Droxinostat (30 μM)-treated PPC-1 cells results in decreased distant tumor formation than untreated cells.

• 细胞实验： PPC-1 cells (1 × 104) are seeded overnight into 96-well flat-bottomed plates in 100 μL of medium containing 2.5% FCS. The next day, Droxinostat is added. CH-11 antibody (100 ng/mL) is then added and the cells are incubated for 24 hours before assessing cell viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) dye reduction assay.(Only for Reference)

• 参考文献：
  1.Wood TE, et al. Mol Cancer Ther, 2010, 9(1), 246-256. 2.Bijangi-Vishehsaraei K, et al. Mol Cell Biochem, 2010, 342(1-2), 133-142. 3.Mawji IA, et al. J Natl Cancer Inst, 2007, 99(10), 811-822. 4.Schimmer AD, et al. Cancer Res, 2006, 66(4), 2367-2375.

• 溶解性： DMSO:46  mg/mL  (188.8  mM)    Ethanol:46  mg/mL  (188.8  mM)    H2O:<1  mg/mL

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	4.104 ml	20.518 ml	41.036 ml
  5 mM	0.821 ml	4.104 ml	8.207 ml
  10 mM	0.41 ml	2.052 ml	4.104 ml
  50 mM	0.082 ml	0.41 ml	0.821 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *