- 提示：详情请下载说明书。
- 产品描述： LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro.
- 靶点： CDK9- Cyclin T1:44 nM (IC50);cdk2-cyclin A;2441 nM (IC50);cdk1-cyclin B1:5513 nM (IC50);cdk4-cyclin D1:9242 nM (IC50);GSK3A:1460 nM (IC50);HGK/MAP4K4:820 nM (IC50);ABL2/ARG:3640 nM (IC50)
- 体外研究： The selectivity of LDC000067 for CDK9 over other CDKs exceeds that of the known inhibitors flavopiridol and DRB. LDC000067 displayed 55/125/210/ >227/ >227-fold selectivity for CDK9 versus CDK2/1/4/6/7. LDC000067 inhibits in vitro transcription in an ATP-competitive and dose-dependent manner. Gene expression profiling of cells treated with LDC000067 demonstrates a selective reduction of short-lived mRNAs, including important regulators of proliferation and apoptosis
- 参考文献：
1. Albert TK, et al. Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor. Br J Pharmacol. 2014 Jan;171(1):55-68.
- 溶解性： soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.7 ml 13.498 ml 26.996 ml 5 mM 0.54 ml 2.7 ml 5.399 ml 10 mM 0.27 ml 1.35 ml 2.7 ml 50 mM 0.054 ml 0.27 ml 0.54 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
