S81219 |
HLCL-61 (hydrochloride) |
| MedMol | 99% |
- 提示：详情请下载说明书。
- 产品描述： HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5).
- 靶点： Protein arginine methyltransferase 5
- 体外研究： HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively[1].HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Cell Viability Assay Cell Line: MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients) Concentration: 1, 5, 10, 25, 50, 100 μM Incubation Time: 24, 48, 72 hours Result: Dose-dependent reduction in cell viability with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.
- 参考文献：
1. Tarighat SS, et al. The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. Leukemia. 2016 Apr;30(4):789-99.
- 溶解性： soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.625 ml 13.126 ml 26.253 ml 5 mM 0.525 ml 2.625 ml 5.251 ml 10 mM 0.263 ml 1.313 ml 2.625 ml 50 mM 0.053 ml 0.263 ml 0.525 ml
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