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• 产品描述： Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC50: 4 μM)

• 靶点： Adenylyl cyclase

• 体内研究： Bithionol (100 mg/kg/day, oral administration for 12 days) is moderately active against immature H. nana in mice. Animal Model: Immature H. nana infected mice Dosage: 100 mg/kg/day Administration: Oral administration, for 12 days post-infection. Result: Eliminated 48% of mature H. nana. LD50: 760 mg/kg.

• 参考文献：
  1. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62. 2. Silke Kleinboelting, et al. Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem. 2016 Apr 29;291(18):9776-84. 3. J Maki, et al. Anthelmintic effects of bithionol, paromomycin sulphate, flubendazole and mebendazole on mature and immature Hymenolepis nana in mice. J Helminthol. 1985 Sep;59(3):211-6.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.809 ml	14.043 ml	28.086 ml
  5 mM	0.562 ml	2.809 ml	5.617 ml
  10 mM	0.281 ml	1.404 ml	2.809 ml
  50 mM	0.056 ml	0.281 ml	0.562 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *