71. [IF=7.9] Zhenghua Sun et al."Folate-modified nanodelivery platform loaded with triptolide for targeted synergistic photothermal therapy of macrophages to alleviate rheumatoid arthritis."MATERIALS & DESIGN.2025 Aug;:114619 70. [IF=5] Haimei Lu et al."Triptolide Inhibits Epileptic Seizures by Rescuing the Neuroinflammation-Related GABAergic Dysfunction in Mice."CNS Neuroscience & Therapeutics.2025 Aug;31(8):e70586 69. [IF=7.9] Zhenghua Sun et al."Folate-modified nanodelivery platform loaded with triptolide for targeted synergistic photothermal therapy of macrophages to alleviate rheumatoid arthritis."MATERIALS & DESIGN.2025 Aug;:114619 68. [IF=12.5] Yongwei Gu et al."Engineering hybrid nanoparticles for targeted codelivery of triptolide and CYP3A4-siRNA against pulmonary metastatic melanoma."Science Advances.2025 Jul;11(30) 67. [IF=4.5] Zhao Xiaomin et al."Targeted metabolic engineering of key biosynthetic genes improves triptolide production in Tripterygium wilfordii hairy roots."PLANT CELL REPORTS.2025 Jun;44(6):1-11 66. [IF=11.5] Yuwen Song et al."Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization."JOURNAL OF CONTROLLED RELEASE.2025 May;:113811 65. [IF=2.1] Ying Zhang et al."Triptolide-Loaded Mesenchymal Stem Cell–Derived Exosomes Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Induction of Nrf-2/HO-1 Signaling Pathway–Dependent Autophagy and Mitigation of MAPK Signaling Pathway."Canadian Respir 64. [IF=3.8] Li Xinglan et al."Triptolide induces apoptosis of glioma cells by inhibiting NF-κB activation during oxidative stress."Scientific Reports.2024 Nov;14(1):1-12 63. [IF=14.3] Aixue Li et al."Cryoshocked Adipocytes Mediated Dual-Modal Strategy Combining Photodynamic Therapy and Triptolide Palmitate for Pulmonary Metastatic Melanoma Treatment."Advanced Science.2025 Jan;:2414307 62. [IF=4.8] Shiyuan Jiang et al."Triptolide combined with salvianolic acid B alleviates CCL4-induced liver fibrosis by suppressing the Th17/IL-17A axis."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Mar;150:114300 61. [IF=6.9] Liuchunyang Yu et al."Application of galactosylated albumin for targeted delivery of triptolide to suppress hepatocellular carcinoma progression through inhibiting de novo lipogenesis."BIOMEDICINE & PHARMACOTHERAPY.2024 Oct;179:117432 60. [IF=14.7] Lai Wang et al."A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus."Acta Pharmaceutica Sinica B.2024 Sep;: 59. [IF=4.8] Li Qiang et al."Novel Detoxifier of Spironolactone Against Triptolide-induced Hepatotoxicity through Inhibition of RPB1 Degradation."JOURNAL OF ETHNOPHARMACOLOGY.2024 Aug;:118722 58. [IF=6.5] Zhe Li et al."Homotypic cell membrane-camouflaged biomimetic PLGA nanoparticle loading triptolide for the treatment of hepatocellular carcinoma."DRUG DELIVERY. 57. [IF=6.1] Qiao-Lei Wang et al."Ultrasensitive upconverting nanoprobes for in situ imaging of drug-induced liver injury using miR-122 as the biomarker."TALANTA".2024 Jul;274:126108 56. [IF=2.9] Hanping Liang et al."Triptolide inhibits esophageal squamous cell carcinoma progression by regulating the circNOX4/miR-153-3p/SATB1 signaling pathway."Thoracic Cancer.2024 Jan;: 55. [IF=5.6] Shiyuan Jiang et al."Triptolide attenuates CCL4-induced liver fibrosis by regulating the differentiation of CD4+ T cells in mice."INTERNATIONAL IMMUNOPHARMACOLOGY.2023 Dec;125:111206 54. [IF=5.1] Wang Qian et al."HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by Activating TRAF6/NFATc1 Signaling."INFLAMMATION.2023 Oct;:1-13 53. [IF=3.3] Wan Lei et al."A novel pharmaceutical preparation of Tripterygium wilfordii Hook. f. regulates macrophage polarization to alleviate inflammation in rheumatoid arthritis."JOURNAL OF PHARMACY AND PHARMACOLOGY.10.1093/jpp/rgad078 52. [IF=7.9] Zhiyan Qin et al."Mitigation of triptolide-induced testicular Sertoli cell damage by melatonin via regulating the crosstalk between SIRT1 and NRF2."PHYTOMEDICINE.2023 Sep;118:154945 51. [IF=3.222] Chenlei Lv et al."Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway."RENAL FAILURE.2023;45(1):Article: 2165103 50. [IF=9.417] Yunan Zhao et al."Engineering adipocytes for targeting delivery of triptolide derivative and Ce6 for malignant melanoma cytotoxic-PDT synergistic strategy."MATERIALS & DESIGN.2023 Apr;228:111860 49. [IF=2.626] Ma, Rui-jiao et al."Kunxian Capsule Extract Inhibits Angiogenesis in Zebrafish Embryos via PI3K/AKT-MAPK-VEGF Pathway."Chinese Journal of Integrative Medicine.2022 Dec;:1-9 48. [IF=3.685] Guoyao Tan et al."MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells."TOXICOLOGY IN VITRO.2023 Feb;86:105487 47. [IF=5.195] Yanqiu Sun et al."Xinfeng capsule inhibits inflammation and oxidative stress in rheumatoid arthritis by up-regulating LINC00638 and activating Nrf2/HO-1 pathway."JOURNAL OF ETHNOPHARMACOLOGY.2023 Jan;301:115839 46. [IF=2.984] Linluo Zhang et al."Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway."Peerj. 2022 Jan;10:e12759 45. [IF=10.435] Li Zhe et al.Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular carcinoma.J Nanobiotechnol. 2021 Dec;19(1):1-12 44. [IF=3.411] Zhou Yuyan et al."Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway."Biomed Res Int. 2020;2020:2508952 43. [IF=4.617] Li Zhe et al."γ-Cyclodextrin metal–organic framework as a carrier to deliver triptolide for the treatment of hepatocellular carcinoma."Drug Delivery and Translational Research. 2021 Apr 15 42. [IF=5.914] Bo Ma et al."Luteolin Ameliorates Testis Injury and Blood–Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43."Mol Nutr Food Res. 2019 May;63(10):1800843 41. [IF=6.419] Yanwen Zheng et al."Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy."Drug Deliv. 2021;28(1):2033-2043 40. [IF=6.684] Yi-Sheng Song et al."Validation, Optimization, and Application of the Zebrafish Developmental Toxicity Assay for Pharmaceuticals Under the ICH S5(R3) Guideline."Front Cell Dev Biol. 2021; 9: 721130 39. [IF=9.229] Liangdi Jiang et al."Engineering Exosomes Endowed with Targeted Delivery of Triptolide for Malignant Melanoma Therapy."Acs Appl Mater Inter. 2021;13(36):42411–42428 38. [IF=2.303] Ingrid Elisia et al."Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators."J Immunol Methods. 2018 Jan;452:26 37. [IF=3.347] Jiamin Kong et al."Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3β by increased SIRT3 expression."Toxicol Appl Pharm. 2018 Mar;342:1 36. [IF=3.585] Jie Zhang et al."MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway."Toxicol Appl Pharm. 2019 May;370:78 35. [IF=5.875] Yongwei Gu et al."Transdermal drug delivery of triptolide-loaded nanostructured lipid carriers: Preparation, pharmacokinetic, and evaluation for rheumatoid arthritis."Int J Pharmaceut. 2019 Jan;554:235 34. [IF=6.4] Li Zhang et al."Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis."Int J Nanomed. 2018; 13: 2051–2064 33. [IF=10.435] Yang Meng et al."Development of triptolide-nanoemulsion gels for percutaneous administration: physicochemical, transport, pharmacokinetic and pharmacodynamic characteristics."J Nanobiotechnol. 2017 Dec;15(1):1-15 32. [IF=10.435] Gu Yongwei et al."Lipid nanoparticles loading triptolide for transdermal delivery: mechanisms of penetration enhancement and transport properties."J Nanobiotechnol. 2018 Dec;16(1):1-14 31. Elisia, Ingrid, et al. "Comparison of RAW264. 7, human whole blood and PBMC assays to screen for immunomodulators." Journal of immunological methods 452 (2018): 26-31.https://doi.org/10.1016/j.jim.2017.10.004 30. Shan, Qian-Qian, et al. "Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide." Drug delivery 26.1 (2019): 490-498.https://doi.org/10.1080/10717544.2019.1602796 29. Yang, Meng, et al. "Development of triptolide-nanoemulsion gels for percutaneous administration: physicochemical, transport, pharmacokinetic and pharmacodynamic characteristics." Journal of nanobiotechnology 15.1 (2017): 1-15.https://doi.org/10.1186/s12951 28. Zhang, Jie, et al. "MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway." Toxicology and applied pharmacology 370 (2019): 78-92.https://doi.org/10.1016/j.taap.2019.03.001 27. 汪五清,贺燕妮,曾义斌,张彤,朱瑞政,左付国.雷公藤甲素固体脂质纳米粒的制备及其抗慢性皮炎湿疹的作用研究[J].上海医药,2021,42(01):14-18+31. 26. 周玉燕,陆萧雅,夏丽,姚伟强,秦国正,王国栋.牛蒡子苷通过抑制炎症通路降低雷公藤甲素所致肾毒性[J].南方医科大学学报,2020,40(10):1399-1405. 25. 曾晶,朱龙.响应曲面法优化雷公藤甲素的微波萃取工艺[J].生物化工,2020,6(04):1-4. 24. 陈琪,周静威,孙满强,李世超,周欢欢,李岩.地黄水提物减轻雷公藤甲素所致肝脏氧化应激损伤的实验研究[J].世界中西医结合杂志,2020,15(12):2241-2245+2251. 23. 周玉燕, 孙玉, 李萍,等. 莫诺苷通过抗氧化应激保护雷公藤甲素所致肝细胞凋亡[J]. 南方医科大学学报, 2018, 038(008):949-955. 22. 臧勇, 田园, 李卫东. 雷公藤甲素通过调节TGF-β1信号通路和Hippo信号通路影响肾小管上皮细胞的上皮-间充质转化[J]. 天津医科大学学报, 2019, 025(003):205-209,224. 21. 方妍妍,万磊,董文哲,文建庭,刘健.雷公藤甲素通过调控VEGFA,SDF-1,CXCR4通路改善强直性脊柱炎患者血小板活化的机制[J].中国中药杂志,2019,44(16):3520-3525. 20. 王爱利, 王蓓蓓, 罗光伟. 雷公藤甲素通过IL-10/Th17细胞调节哮喘小鼠气道炎症[J]. 内科急危重症杂志, 2019, 25(4). 19. 万磊,刘健,黄传兵,张晓军,王亚黎,章平衡,孙玥,刘磊.雷公藤甲素调节佐剂关节炎大鼠滑膜、脾脏、胸腺组织细胞自噬的实验研究[J].四川大学学报(医学版),2017,48(04):520-525. 18. 罗国平, 孟会宁, 闫梦茹,等. 雷公藤甲素热敏醇质体的制备工艺[J]. 化工科技, 2020, 028(002):46-51. 17. 罗国平, 闫梦茹, 孟会宁,等. 雷公藤甲素普通脂质体与包合物脂质体体外释药特点对比分析[J]. 化工科技, 2020, 028(001):32-36. 16. 李文,杨莉莉,王东明,何翔,丁佩军,贺旭锋,边风华,赵晓娴,陈文君,张慧敏.雷公藤甲素对黑色素瘤A375细胞EMT通路及侵袭能力的作用研究[J].上海中医药杂志,2020,54(S1):153-155. 15. 李文化, 白雪梅, 吴耀东,等. 雷公藤甲素对早期2型糖尿病大鼠肾脏的保护作用[J]. 河北北方学院学报(自然科学版), 2015, 000(005):77-80. 14. 万磊, 刘健, 黄传兵,等. 雷公藤甲素对关节炎大鼠心功能的影响及其作用机制探讨[J]. 四川大学学报(医学版), 2020, v.51(02):82-87. 13. 陈宁南, 万强. 雷公藤甲素对PM2.5损伤足细胞的保护作用. 12. 陈凯丽, 易剑峰, 翟文静,等. 雷公藤甲素在正常大鼠和佐剂性关节炎模型大鼠体内的药动学研究[J]. 中国药房, 2017, 28(7):923-923. 11. 戴媛媛, 高寒, 刘嫦钦,等. 雷公藤多甙对实验性结肠炎大鼠Th17/Treg细胞分化和平衡的影响[J]. 胃肠病学, 2020, v.25(02):26-31. 10. 范兆峰, 归小龙, 黄赛杰. 用LC/MS法测定雷公藤甲素纳米乳中雷公藤甲素的含量[J]. 药学服务与研究, 2018, v.18(06):50-53. 9. 汪文强, 邓奇, 肖安菊. 湖北黄石野生驯化扦插雷公藤芽、叶中雷公藤甲素的含量分析[J]. 广州中医药大学学报, 2016, 33(006):868-871. 8. 郑德杉, 王三亚, 汪文强,等. 样品处理方法对雷公藤叶中雷公藤甲素含量测定结果的影响[J]. 湖北理工学院学报, 2016, 32(004):58-61. 7. 周玉燕, 王明艳, 潘学娟,等. 斑蝥酸钠协同雷公藤甲素诱导肝癌细胞株7721凋亡[J]. 中南大学学报(医学版), 2016, 41(9):911-917. 6. 黄国东,淮国丽,杨洪吉,王轶,向少伟,覃振林,庞健丽,罗欢,张亚萍,刘振威,许健,吕建珍.复方仙草颗粒对人肾足细胞保护作用的研究[J].北京中医药,2017,36(05):410-415+481. 5. 杨盟, 杨帝顺, 顾永卫,等. 基于皮肤,血液双位点同步微透析技术的雷公藤甲素纳米乳体内药动学研究[J]. 中国药学杂志, 2018, 053(011):894-899. 4. 李芳琼, 赵东晓, 王娟,等. 基于iTRAQ技术分析不同浓度的雷公藤甲素作用肺癌细胞后的差异蛋白表达[J]. 中国新药杂志, 2018(11). 3. 陈琪, 孙满强, 李世超,等. 地黄水提物对雷公藤甲素致肝损伤的减毒作用及抗氧化机制[J]. 上海中医药大学学报, 2020(4):47-52. 2. 曾晶 朱龙.响应曲面法优化雷公藤甲素的微波萃取工艺[J].生物化工 2020 6(04):1-4. 1. 赵东晓 陈弘磊 孟冠敏 等. 低浓度雷公藤甲素联合顺铂对肝癌细胞HepG2活性的影响[J]. 浙江中西医结合杂志 2017年27卷5期 366-369页 2017.