51. [IF=3.1] Xinyi Jiao et al."A multi-level strategy based on comprehensive two-dimensional liquid chromatography-Q-Orbitrap-mass spectrometry combined with PLS regression model and RT-Ensemble Pred model to intelligently distinguish different geographical locations 50. [IF=2.8] Jingbo Yu et al."Non-target metabolomics unravels the effect and mechanism of Lianpu Drink on spleen-stomach damp-heat syndrome."JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.2024 Oct;1246:124281 49. [IF=2.5] Li Chen et al."Optimization of Extraction Process of Total Alkaloids from Thalictrum delavayi Franch. and Their Therapeutic Potential on Pulmonary Infection Caused by Klebsiella pneumoniae and Escherichia coli."Separations.2024 Jul;11(7):210 48. [IF=3] Haiwen Zhang et al."Alkaloid profiling of the new species Corydalis huangshanensis and other 13 medicinal plants in genus Corydalis."PHYTOCHEMICAL ANALYSIS.2024 Jul;: 47. [IF=4.1] Huaixin Liu et al."A magnetic beads-based ligand fishing method for rapid discovery of monoterpene indoles as monoamine oxidase A inhibitors from Hunteria zeylanica."JOURNAL OF CHROMATOGRAPHY A".2024 May;1722:464896 46. [IF=4.9] Xueyu Pu et al."Lipids Extracted from Mycobacterial Membrane and Enveloped PLGA Nanoparticles for Encapsulating Antibacterial Drugs Elicit Synergistic Antimicrobial Response against Mycobacteria."MOLECULAR PHARMACEUTICS".2024;21(5):2238–2249 45. [IF=7.9] Kaifan Hu et al."Effect of Pulsatilla decoction on vulvovaginal candidiasis in mice. Evidences for its mechanisms of action."PHYTOMEDICINE".2024 Mar;:155515 44. [IF=3.4] Jiaping Zhang et al."Effect of the Pulsatilla decoction n-butanol extract on vulvovaginal candidiasis caused by Candida glabrata and on its virulence factors."FITOTERAPIA.2024 Mar;173:105825 43. [IF=7.9] Shan Zhang et al."Enhancing β-Cell Function and Identity in type 2 diabetes: The Protective Role of Coptis deltoidea C. Y. Cheng et Hsiao via Glucose Metabolism Modulation and AMPK Signaling Activation."PHYTOMEDICINE.2024 Jan;:155396 42. [IF=4] Lewen Xiong et al."Study on Antipyretic Properties of Phenolics in Lonicerae Japonicae Flos Based on Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry Combined with Network Pharmacology."JOURNAL OF FOOD BIOCHEMISTRY.2023;2023:8883860 41. [IF=3.4] Rongrong Li et al."Chemical profiles, Differentiation, and Quality evaluation of Radix et Rhizoma Thalictri Foliolosi based on LC-MS."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.10.1016/j.jpba.2023.115747 40. [IF=4.6] Fengge YANG et al."Deciphering chemical and metabolite profiling of Chang-Kang-Fang by UPLC-Q-TOF-MS/MS and its potential active components identification."Chinese Journal of Natural Medicines.2023 Jun;21:459 39. [IF=4.8] Mingyi Yao et al."In situ detection of natural dyes in archaeological textiles by SERS substrates immobilized on the fiber."MICROCHEMICAL JOURNAL.2023 Sep;192:108939 38. [IF=6.5] Wei Liu et al."Genome-wide analysis of bHLH gene family in Coptis chinensis provides insights into the regulatory role in benzylisoquinoline alkaloid biosynthesis."PLANT PHYSIOLOGY AND BIOCHEMISTRY.2023 Aug;201:107846 37. [IF=5.988] Yuanmei Bai et al."Mechanisms of Yajieshaba in the treatment of liver fibrosis through the Keap1-Nrf2 signaling pathway."Frontiers in Pharmacology.2023; 14: 1124015 36. [IF=0] Xiaoming Yin et al."Assessment of alkaloids from the stems of 14 Berberis species in China."Separation Science Plus.2022 Dec;:202200114 35. [IF=5.195] Kaifan Hu et al."Effects of n-butanol extract of Pulsatilla decoction on the NLRP3 inflammasome in macrophages infected with Candida albicans."JOURNAL OF ETHNOPHARMACOLOGY.2022 Dec;:116041 34. [IF=7.291] Yu Yuetong et al."Functional characterization and key residues engineering of a regio-promiscuity O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in Nelumbo nucifera."Horticulture Research.2022 Dec;: 33. [IF=2.838] Wang Shuo et al."Toxicity and toxicokinetics of the ethanol extract of Zuojin formula."BMC Complementary Medicine and Therapies.2022 Dec;22(1):1-14 32. [IF=3.614] Huanyu Guan et al."Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultra-high-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resis 31. [IF=7.291] Bu Junling et al."Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids."Horticulture Research.2022 Jul;: 30. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825 29. [IF=2.351] Juanjuan Liu et al."Antifungal evaluation of traditional herbal monomers and their potential for inducing cell wall remodeling in Candida albicans and Candida auris."Biofouling. 2020;36(3):319-331 28. [IF=3.004] Kai Zhang et al."Untargeted metabolomics reveals the synergistic mechanisms of Yuanhu Zhitong oral liquid in the treatment of primary dysmenorrhea."J Chromatogr B. 2021 Feb;1165:122523 27. [IF=3.463] Xiao-Meng Liu et al."Comparative transcriptome analysis provides novel insights into the molecular mechanism of berberine biosynthesis in Coptis chinensis."Sci Hortic-Amsterdam. 2022 Jan;291:110585 26. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820 25. [IF=3.963] Zhong-min Zhao et al."Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine."Pestic Biochem Phys. 2019 Sep;159:51 24. [IF=11.413] Sifan Luo et al."Rapid identification and isolation of neuraminidase inhibitors from mockstrawberry (Duchesnea indica Andr.) based on ligand fishing combined with HR-ESI-Q-TOF-MS."Acta Pharm Sin B. 2020 Oct;10:1846 23. [IF=1.618] Li Jiang-Yan et al."Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods."J Chromatogr Sci. 2015 Aug;53(7):1131-1139 22. [IF=2.419] Kun Wang et al."Identification of metabolites of palmatine in rats after oral administration using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry."Rapid Commun Mass Sp. 2017 Mar;31(6):523-537 21. [IF=2.882] Kun Wang et al."Identification of berberrubine metabolites in rats by using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry."Fitoterapia. 2018 Jan;124:23 20. [IF=3.361] Huanyu Guan et al."Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out 19. [IF=3.935] Kun Wang et al."Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry."J Pharmaceut Biomed. 2017 May;139:73 18. [IF=3.935] Ka-Yan Kwok et al."Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography."J Pharmaceut Biomed. 2013 Nov;85:239 17. [IF=4.411] Jinjun Shan et al."Liquid Chromatography Coupled with Linear Ion Trap Hybrid OrbitrapMass Spectrometry for Determination of Alkaloids in Sinomeniumacutum."Molecules. 2018 Jul;23(7):1634 16. [IF=4.759] Yanyan Zhang et al."Rapid screening and identification of monoamine oxidase-A inhibitors from Corydalis Rhizome using enzyme-immobilized magnetic beads based method."J Chromatogr A. 2019 May;1592:1 15. [IF=6.023] Ling Zhu et al."Coptis chinensis inflorescence extract protection against ultraviolet-B-induced phototoxicity, and HPLC–MS analysis of its chemical composition."Food Chem Toxicol. 2012 Jul;50:2584 14. [IF=6.057] Zhihong Li et al."New MS network analysis pattern for the rapid identification of constituents from traditional Chinese medicine prescription Lishukang capsules in vitro and in vivo based on UHPLC/Q-TOF-MS."Talanta. 2018 Nov;189:606 13. Chen, Meng, et al. "Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate." Journal of Pharmaceutical and Biomedical Analysis 195 (2021): 113820.https:// 12. Wang, Kun, et al. "Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry." Journal of pharmaceutical and biomedical analysis 139 (2017): 73-86.https://doi.org/10.1016/ 11. Wang, Kun, et al. "Identification of metabolites of palmatine in rats after oral administration using ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry." Rapid Communications in Mass Spectrometry 31.6 (2017): 523-537. 10. Zhu, Ling, et al. "Coptis chinensis inflorescence extract protection against ultraviolet-B-induced phototoxicity, and HPLC–MS analysis of its chemical composition." Food and chemical toxicology 50.7 (2012): 2584-2588.https://doi.org/10.1016/j.fct.2012.04.0 9. 纪万里,周泽华,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏泻心汤化学成分[J].药物分析杂志,2020,40(10):1736-1750. 8. 李听弦 李蒙 张志 等. 一测多评法测定不同味连饮片中6个生物碱类成分的含量[J]. 药物分析杂志 2018 038(007):1132-1138. 7. 张久旭, 范晶, 李小阳,等. 基于内在品质的黄连药材现代产地加工方法研究[J]. 辽宁中医药大学学报, 2019, v.21;No.185(09):74-77. 6. 李听弦, 李蒙, 张志,等. 基于高效液相色谱指纹图谱及红外光谱评价黄连及其炮制品质量差异[J]. 中南药学, 2019, 017(004):556-560. 5. 皮文霞 朱鑫仙 方婷 等. HPLC同时测定"三热论"方各纯化部位中药根碱、表小檗碱、黄连碱、巴马汀和小檗碱的含量[J]. 中国实验方剂学杂志 2012 18(14):110-113. 4. 严赟, 张赟赟. HPLC-ESI-MS/MS同时测定金果榄中5种成分含量[J]. 中药材, 2017, 40(002):395-398. 3. 张赟赟,李嘉.HPLC-ESI-MS/MS法同时测定金线风中7种有效成分[J].中华中医药杂志,2017,32(06):2762-2764. 2. 王书宁, 祝洪艳, 郜玉钢,等. 黄藤总生物碱回流提取工艺的优化[J]. 中成药, 2018, 040(006):1399-1403. 1. 林才志, 张贇赟, 段雪琳,等. 壮药汗衣台抗HBV有效成分分析及对HBVDNA、HBVcccDNA的影响[J]. 中药药理与临床, 2018, v.34;No.193(01):59-64.