58. [IF=3.6] Zhiwei Wang et al."Design, synthesis and biological evaluation of novel β-caryophyllene derivatives as potential anti-cancer agents through the ROS-mediated apoptosis pathway."RSC Medicinal Chemistry.2025 May;: 57. [IF=3.9] Zhiwei Wang et al."Synthesis, anticancer and antibacterial evaluation of novel spiramycin-acylated derivatives."RSC Advances.2024 Dec;14(52):38898-38907 56. [IF=4] Yinyin Gao et al."Weizmannia coagulans BC99 alleviates hyperuricemia and oxidative stress via DAF-16/SKN-1 activation in Caenorhabditis elegan."Frontiers in Microbiology.2024 Dec;15: 55. [IF=1.6] FUSHENG ZHOU et al."Circular RNA hsa_circ_0004650 Enhances 5-Fluorouracil Resistance in Gastric Cancer via Sponging miR-145-5p."ANTICANCER RESEARCH.2025 Jan;45(1):173-187 54. [IF=6.2] Peng Yu et al."Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice."Current Research in Food Science.2025 Jan;10:100978 53. [IF=3.9] Qile Xia et al."Inhibitory effect and mechanism of purified saponin from Polygonatum cyrtonema Hua on human ovarian cancer cell A2780."FOOD AND CHEMICAL TOXICOLOGY.2025 Mar;:115368 52. [IF=6.6] Wenhui Zhang et al."Core-Shell Magnetic Nanocarriers: Fe3O4-Hydroxyapatite/Polysuccinimide Hybrids for Enhanced Oral Bioavailability of Fluorouracil."International Journal of Nanomedicine. 51. [IF=1.3] Yan-Yuan Zhou et al."Rhamnocitrin induces apoptosis of human nasopharyngeal carcinoma by inhibiting IGF-1R signaling pathway in vitro."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. 50. [IF=4.2] Pengxia Gao et al."Sensitive Detection of Genotoxic Substances in Complex Food Matrices by Multiparametric High-Content Analysis."MOLECULES.2024 Jan;29(14):3257 49. [IF=11.4] Zhipeng Wang et al."Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway."Journal of Advanced Research.2024 Jul;: 48. [IF=0.8] Cao Yezhi et al."Cryptotanshinone Inhibits the Proliferation of 5-Fluorouracil-Resistant Gastric Cancer SGC-7901/5-FU Cells Via the JAK2/STAT3 Pathway."PHARMACEUTICAL CHEMISTRY JOURNAL.2024 Jun;:1-10 47. [IF=4.4] Qu Minmin et al."Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells."Frontiers in Pharmacology.2024 Jun;15: 46. [IF=8.2] Yanzhe Chen et al."Selenium nanoparticles stabilized by Sargassum fusiforme polysaccharides: Synthesis, characterization and bioactivity."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES".2024 Jun;269:132073 45. [IF=3.9] Chen Jiaxin et al."Ginsenoside compound K induces ferroptosis via the FOXO pathway in liver cancer cells."BMC Complementary Medicine and Therapies".2024 Dec;24(1):1-13 44. [IF=4.6] Yutao FENG et al."Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8+ T cell proportion in tumor-bearing mice through the USP9X signaling pathway."Chinese Journal of Natural Medicines".2024 Apr;22:329 43. [IF=1.8] Xue Wang et al."Integrated UHPLC-Q-Orbitrap-MS/MS Method and Network Pharmacology for Exploring the Active Components and Potential Mechanisms of Neuroprotective Effect of the n-Butanol Part of Mume Flos."Natural Product Communications.10.1177/1934578X241 42. [IF=2.3] Li Xiang et al."Hydroxypropyl β-cyclodextrin-crosslinked konjac glucomannan supramolecular hydrogel as dual-action drug carrier for a sustained release."JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY.2024 Jan;:1-14 41. [IF=20.1] Zhou Jianfeng et al."Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance."Advanced Composites and Hybrid Materials.2023 Dec 40. [IF=3.9] Zhao Zhongwei et al."Anticancer potential of Bacillus coagulans MZY531 on mouse H22 hepatocellular carcinoma cells via anti-proliferation and apoptosis induction."BMC Complementary Medicine and Therapies.10.1186/s12906-023-04120-7 39. [IF=9.9] Yi Xia et al."Tumor microenvironment-activated, immunomodulatory nanosheets loaded with copper(II) and 5-FU for synergistic chemodynamic therapy and chemotherapy."JOURNAL OF COLLOID AND INTERFACE SCIENCE.10.1016/j.jcis.2023.09.042 38. [IF=3.9] Yan Wu et al."Effect of preserved eggs on the health of SD rats, and anti-tumor action of HT-29 cells."Food Science & Nutrition.2023 Jul;: 37. [IF=18.9] Mengying Hong et al."Martynoside rescues 5-fluorouracil-impaired ribosome biogenesis by stabilizing RPL27A."Science Bulletin.2023 Jul;: 36. [IF=6.429] Ge, Chun et al."In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer."Cancer Cell International.2023 Dec;23(1):1-20 35. [IF=3.268] Jiaxin Chen et al."Ginsenoside compound K induces mitochondrial apoptosis in human hepatoma cells through Bclaf1-mediated modulation of ERK signaling."FOOD AND AGRICULTURAL IMMUNOLOGY 34. [IF=3.204] Zhong-Bo Zhou et al."Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum scabrum."FITOTERAPIA.2022 Sep;161:105249 33. [IF=4.004] Shuangshuang Xie et al."Epimesatines A–I, nine undescribed prenylated flavonoids with SPHK1 inhibitory activities from Epimedium sagittatum maxim."PHYTOCHEMISTRY.2022 Jul;:113314 32. [IF=6.388] Yufei Zhai et al."Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway."PHYTOTHERAPY RESEARCH 31. [IF=8.039] Haohao Wang et al."Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle."JOURNAL OF MEDICINAL CHEMISTRY.2022;XXXX(XXX):XXX-XXX 30. [IF=7.376] Chengtao Sun et al."Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation."Free Radical Bio Med. 2022 Feb;180:220 29. [IF=1.679] Zhong-Bo Zhou et al."Two new polycyclic polyprenylated acylphloroglucinols from Hypericum curvisepalum N. Robson."Phytochem Lett. 2022 Apr;48:43 28. [IF=2.898] Zhe Deng et al."Synergistic anti-liver cancer effects of curcumin and total ginsenosides."World J Gastro Oncol. 2020 Oct 15; 12(10): 1091–1103 27. [IF=3.565] Liqiang Qian et al."Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer."J Cancer. 2020; 11(11): 3114–3123 26. [IF=3.565] Bolin Yang et al."Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells."J Cancer. 2020; 11(8): 2303–2317 25. [IF=4.076] Xinyuan Wang et al."Novel Formulations of the Antiviral Drug Favipiravir: Improving Permeability and Tabletability."Cryst Growth Des. 2021;21(7):3807–3817 24. [IF=5.81] Huixia Feng et al."Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration."Front Pharmacol. 2021; 12: 749189 23. [IF=6.331] Zhi Liao et al."Hydroxychloroquine based chemical drug for combination therapy with 5-Fu for inhibiting the pathway of Akt/mTOR in autophagy process on colon cancer."J Mater Chem B. 2021 May;: 22. [IF=2.563] Zhang Huidan et al."Heavy ion mutagenesis combined with triclosan screening provides a new strategy for improving the arachidonic acid yield in Mortierella alpina."Bmc Biotechnol. 2018 Dec;18(1):1-9 21. [IF=3.534] Wenfeng Ni et al."Dual-Targeting Nanoparticles: Codelivery of Curcumin and 5-Fluorouracil for Synergistic Treatment of Hepatocarcinoma."J Pharm Sci-Us. 2019 Mar;108:1284 20. [IF=4.411] Xiaoxu Gao et al."Comparative Analysis of Chemical Composition, Anti-Inflammatory Activity and Antitumor Activity in Essential Oils from Siegesbeckia orientalis, S. glabrescens and S. pubescens with an ITS Sequence Analysis."Molecules. 2018 Sep;23(9):2185 19. [IF=6.304] Jiang Ying et al."Furanodienone induces G0/G1 arrest and causes apoptosis via the ROS/MAPKs-mediated caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo."Cell Death Dis. 2017 May;8(5):e2815-e2815 18. Ni, Wenfeng, et al. "Dual-targeting nanoparticles: codelivery of curcumin and 5-fluorouracil for synergistic treatment of hepatocarcinoma." Journal of pharmaceutical sciences 108.3 (2019): 1284-1295.https://doi.org/10.1016/j.xphs.2018.10.042 17. Gao, Xiaoxu, et al. "Comparative analysis of chemical composition, anti-inflammatory activity and antitumor activity in essential oils from Siegesbeckia orientalis, S. glabrescens and S. pubescens with an ITS sequence analysis." Molecules 23.9 (2018): 2185 16. Zhang, Huidan, et al. "Heavy ion mutagenesis combined with triclosan screening provides a new strategy for improving the arachidonic acid yield in Mortierella alpina." BMC biotechnology 18.1 (2018): 1-9. 15. 夏天,韩海霞,冯伟,方丽君,付霞.重楼皂苷Ⅶ对裸鼠胰腺癌的治疗作用及机制研究[J].广州中医药大学学报,2021,38(04):785-790. 14. 刘文静, 杨稳, 刘飞,等. 鼠妇抗肿瘤活性物质初步探究[J]. 辽宁中医药大学学报, 2017, 10(v.19;No.162):17-20. 13. 谢飞, 李伟, 陈美珍,等. 野生蝉花多糖抗肿瘤活性及其作用机制[J]. 食品科学, 2016, 37(13):209-213. 12. 贺宝元,张宝艳,李珊,薛海燕. 载5-氟尿嘧啶壳聚糖/明胶微粒的制备及药物释放性能[J]. 化工进展(7期):2151-2155. 11. 张婷婷, 周琢艳, 李俊峰,等. 解毒祛瘀滋阴方对H22荷瘤小鼠肿瘤生长及免疫功能的影响[J]. 浙江中医杂志, 2019, 54(03):176-177. 10. 鞠瑶瑶, 叶天文, 谢飞,等. 脆江蓠多糖体内抗肿瘤活性及其作用机制[J]. 食品科学, 2016, 037(005):208-213. 9. 吴演, 杨瑞琦, 陈美珍,等. 海蓬子籽油亚油酸共轭化产物的抗肿瘤作用[J]. 食品科学, 2012, 033(023):318-322. 8. 鞠瑶瑶 曹纯洁 陈美珍 叶天文.响应面试验优化脆江蓠多糖提取工艺及其对肿瘤细胞的抑制作用[J].食品科学 2016 37(08):57-62. 7. 谢飞 曹纯洁 陈美珍 等. 响应面试验优化末水坛紫菜多糖除蛋白工艺及其抗氧化活性[J]. 食品科学 2016 37(22):77-84. 6. 阮善明 沈敏鹤 王益 林红 郑丽萍 李梦婷 张恺.中医解毒法优化干预对BALB/c结肠癌小鼠CEA、sCD44的实验研究[J].世界中医药 2013 8(03):313-317. 5. 阮善明 沈敏鹤 王益 林红 郑丽萍 李梦婷 张恺.中医解毒法优化干预对BALB/c结肠癌小鼠总生存期及Caspase-3、ROCK2、mTOR表达的影响[J].中华中医药杂志 2013 28(06):1714-1718. 4. 钟思恩 刘杨 曹纯洁 等. 三种多糖降解复合物体外抑制HeLa细胞的增殖作用[J]. 现代食品科技 2018 034(010):72-80 7. 3. 张鲁杰 郭义兵 石璐 等. P(γ-PGA-co-NIPAAm)水凝胶对5-氟尿嘧啶药物分子的释放行为[J]. 功能高分子学报 2015(01):91-96. 2. 万永兴 朱金丽 孙同明 等. 4-(5'-氟尿嘧啶甲基)-3-硝基苯甲酸的合成及光控性能[J]. 化学试剂 2019(11). 1. 谢好贵 韦明钎 陈美珍 等. 3种多糖复合体外抗肿瘤协同增效作用[J]. 食品科学 2013(15):289-294.