77. [IF=5.4] Zhimin Zhu et al."Screening and Assessment of Hypoglycemic Active Peptide from Natural Edible Pigment Phycobiliprotein Based on Molecular Docking, Network Pharmacology, Enzyme Inhibition Assay Analyses, and Cell Experiments."Marine Drugs.2025 Aug;23(8):331 76. [IF=8.2] Yao Meng et al."Mutational analysis of TXNRD1 reveals the essential role of Trp114 in TRP14 reduction and identifies key determinants of enzymatic activity and thermostability."FREE RADICAL BIOLOGY AND MEDICINE.2025 Jul;: 75. [IF=8.5] Yan-Li Li et al."Probiotic fermentation of Polygonatum plant polysaccharides converting fructans to glucans with enhanced anti-obesity activity."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Jul;:145871 74. [IF=16] Xinyue Zhang et al."Glucose-Responsive Polyzwitterionic Nanoparticles with Enhanced and Targeted Intestinal Epithelial Absorption for Oral Insulin Delivery."ACS Nano.2025;19(29):26871–26881 73. [IF=2.5] Yi Li et al."MiR-21-5p enhances differentiation and mitigates oleic acid-induced lipid droplet accumulation in C2C12 myoblasts by targeting FBXO11."Animal Bioscience.2025 Jun;38(6):1279-1290 72. [IF=5.1] Dan Wang et al."A smart nanocomposite system for controlled insulin release and glucose sensing in diabetes management."Nanoscale.2025 Jun;: 71. [IF=5.4] Xiaojie Qin et al."Self-Assembled Keratin Nanoparticles Prepared by Partial Hydrolysis and Their Restructuring Response to pH Shifting for Biomolecule Encapsulation."BIOMACROMOLECULES.2025;XXXX(XXX):XXX-XXX 70. [IF=8.2] Meihua Zhang et al."Lactobacillus plantarum 1-2-3 inhibits ferroptosis by regulating dysregulated fatty acid metabolism to protect mice from high-fat diet-induced MAFLD."FREE RADICAL BIOLOGY AND MEDICINE.2025 Oct;238:137 69. [IF=6.2] Beijun Ang et al."Enzymatic Synthesis and Evaluation of Eight Methylated Quercetin Products: In Vitro Chemical Properties and Adipogenesis Regulation."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2025;73(22):13973–13984 68. [IF=6.5] Weihong Guo et al."In vitro digestion and fecal fermentation behaviors of exopolysaccharide from Morchella esculenta and its impacts on hypoglycemic activity via PI3K/Akt signaling and gut microbiota modulation."Food Chemistry-X.2024 Dec;24:101870 67. [IF=2.9] Nianmeng Wang et al."Sublethal concentration of λ-cyhalothrin inhibits insulin-like peptides and leads to reproductive toxicity in Chrysoperla sinica."Insect Science.2024 Oct;: 66. [IF=5.5] Ling Wang et al."Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells."FEBS Journal.2024 Oct;: 65. [IF=5.7] Zeqiang Ma et al."Overexpression of ALDOC Promotes Porcine Intramuscular and Intermuscular Fat Deposition by Activating the AKT-mTORC1 Signaling Pathway."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2024;72(43):23893–23907 64. [IF=8.5] Hongcheng Liu et al."Exploring novel antioxidant cyclic peptides in corn protein hydrolysate: Preparation, identification and molecular docking analysis."FOOD CHEMISTRY.2025 Feb;464:141747 63. [IF=4.2] Xueling Zhang et al."Separation, Purification, Structural Characterization, and In Vitro Hypoglycemic Activity of Polysaccharides from Panax notoginseng Leaves."MOLECULES.2025 Jan;30(4):830 62. [IF=7.7] Nannan Liu et al."In vitro fermentation of Auricularia auricula polysaccharides and their regulation of human gut microbiota and metabolism."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 May;306:141714 61. [IF=3.8] Jiang Yike et al."Multi-omic analyses reveal aberrant DNA methylation patterns and the associated biomarkers of nasopharyngeal carcinoma and its cancer stem cells."Scientific Reports.2025 Mar;15(1):1-14 60. [IF=5.6] Wenxiao Wang et al."The total tannins of Geum japonicum Thunb. var. chinense extracted by green and natural deep eutectic solvent: Extraction optimization, component identification and hypoglycemic activity."INDUSTRIAL CROPS AND PRODUCTS.2024 Dec;222:1196 59. [IF=4.9] Dalan Jin et al."A minimally invasive sensing system based on hydrogel microneedle patches and Au/Cu2O nanospheres modified screen-printed carbon electrode for glucose monitoring in interstitial skin fluid."MICROCHEMICAL JOURNAL.2024 Oct;205:111367 58. [IF=6.9] Xiaojie Hu et al."A novel experimental mouse model of diabetic nonalcoholic steatohepatitis: A critical role for acid-sensitive Ion Channel 1a."BIOMEDICINE & PHARMACOTHERAPY.2024 Sep;178:117184 57. [IF=10] Kofi Oti Boakye-Yiadom et al."Injectable Gelled Multiple Emulsion for Glucose-Responsive Insulin Delivery."Advanced Healthcare Materials.2024 Jul;:2304195 56. [IF=8.1] Yingqi Zhang et al."A symbiont fungal effector relocalizes a plastidic oxidoreductase to nuclei to induce resistance to pathogens and salt stress."CURRENT BIOLOGY. 55. [IF=8.8] Jiayuan Luo et al."Interaction between lactic acid bacteria and Polygonatum sibiricum saponins and its application to microencapsulated co-delivery."FOOD CHEMISTRY".2024 Aug;448:138959 54. [IF=4.9] Liu Pei-Yu et al."Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease."Chinese Medicine".2024 Dec;19(1):1-13 53. [IF=3.8] Xiangyuan Zhao et al."Inhibition of insulin fibrillation by carboxyphenylboronic acid-modified chitosan oligosaccharide based on electrostatic interactions and hydrophobic interactions."BIOPHYSICAL CHEMISTRY".2024 Jul;310:107236 52. [IF=10.8] Wei Ji et al."Hydrogel-encapsulated medium chain lipid-modified zeolite imidazole framework-90 as a promising platform for oral delivery of proteins."JOURNAL OF CONTROLLED RELEASE.2024 Mar;367:93 51. [IF=4.1] Lanqi Zhou et al."'Nine Steaming Nine Sun-drying' processing enhanced properties of Polygonatum kingianum against inflammation, oxidative stress and hyperglycemia."JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE.2023 Dec;: 50. [IF=16.6] Zhao Zheng et al."5mC modification orchestrates choriogenesis and fertilization by preventing prolonged ftz-f1 expression."Nature Communications.2023 Dec;14(1):1-14 49. [IF=6.1] Mingyuan Cao et al."Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2023;XXXX(XXX):XXX-XXX 48. [IF=4.6] Long CHENG et al."Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway."Chinese Journal of Natural Medicines.2023 Nov;21:812 47. [IF=4.6] Minghui Liu et al."Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase."MOLECULES.10.3390/mol 46. [IF=6] Chenchen Cao et al."Effect of fermentation with Tetragenococcus halophilus and Zygosaccharomyces rouxii on selected non-volatile taste compounds in soybean protein hydrolysates."LWT-FOOD SCIENCE AND TECHNOLOGY.2023 Jul;:115053 45. [IF=5.8] Jiaying Zhang et al."Chitosan-based injectable hydrogels with dual glucose sensors for precise control of insulin release and diabetes mellitus therapy."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2023 Aug;643:123246 44. [IF=7.571] Jing Liu et al."Glucose-sensitive poly(ether sulfone) composite membranes blended with phenylboronic acid-based amphiphilic block copolymer for self-regulated insulin release."Journal of Materials Chemistry B.2023 Jun;11(22):5000-5009 43. [IF=6.317] Shiqing Sun et al."Pharmacodynamic structure of deer antler base protein and its mammary gland hyperplasia inhibition mechanism by mediating Raf-1/MEK/ERK signaling pathway activation."Food & Function.2023 Mar;: 42. [IF=7.59] Li Yang et al."Transformational Shapes and Shrunk Size of Acid-resistant Metal–organic frameworks (MOFs) as the Vehicle of Oral Protein."Biomaterials Science.2023 Mar;: 41. [IF=3.605] Jing-Xiang Chen et al."Comparison of the signaling pathways of wing dimorphism regulated by biotic and abiotic stresses in the brown planthopper."Insect Science.2022 Nov;: 40. [IF=5.895] Haiping Du et al."Fu Brick Tea Polysaccharides Prevent Obesity via Gut Microbiota-Controlled Promotion of Adipocyte Browning and Thermogenesis."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2022;70(43):13893–13903 39. [IF=2.213] Jing Yao et al."Fabrication of Silica Microspheres for HPLC Packing with Narrow Particle Size Distribution and Different Pore Sizes by Hard Template Method for Protein Separation."CHROMATOGRAPHIA.2022 Sep;:1-11 38. [IF=5.561] Wenrui Liu et al."Peanut Shell Extract and Luteolin Regulate Lipid Metabolism and Induce Browning in 3T3-L1 Adipocytes."Foods.2022 Jan;11(17):2696 37. [IF=5.999] Mingze Xu et al."Construction of a double-responsive modified guar gum nanoparticles and its application in oral insulin administration."COLLOIDS AND SURFACES B-BIOINTERFACES.2022 Dec;220:112858 36. [IF=6.317] Haiping Du et al."Fu brick tea protects against high-fat diet-induced obesity phenotypes via promoting adipose browning and thermogenesis in association with gut microbiota."Food & Function.2022 Sep;: 35. [IF=6.208] Qi Chen et al."12/15-Lipoxygenase Regulation of Diabetic Cognitive Dysfunction Is Determined by Interfering with Inflammation and Cell Apoptosis."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(16):8997 34. [IF=8.697] Li-Shan Yan et al."Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway."Metabolism. 2022 Apr;:155200 33. [IF=7.514] Lu Han et al."Effects of inducer type and concentration on the formation mechanism of W/O/W double emulsion gels."Food Chem. 2022 Jun;379:132166 32. [IF=4.158] Zhu Shenglong et al."Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis."J Physiol Biochem. 2022 Feb;:1-12 31. [IF=6.331] Zhaoyang Guo et al."Responsive hydrogel-based microneedle dressing for diabetic wound healing."J Mater Chem B. 2022 Mar;: 30. [IF=4.534] Jingwei Zhang et al.Ndufa6 regulates adipogenic differentiation via Scd1.Adipocyte. 2021;10(1):646-657 29. [IF=3.665] Zhenyu Xu et al."Microparticles based on alginate/chitosan/casein three-dimensional system for oral insulin delivery."Polym Advan Technol. 2021 Nov;32(11):4352-4361 28. [IF=4.36] Pin Gong et al."Hypoglycemic effect of astragaloside IV via modulating gut microbiota and regulating AMPK/SIRT1 and PI3K/AKT pathway."J Ethnopharmacol. 2021 Dec;281:114558 27. [IF=4.966] Yifan Wang et al."Intestinal microbiota contributes to altered glucose metabolism in simulated microgravity mouse model."Faseb J. 2019 Sep;33(9):10140-10151 26. [IF=6.331] Yujie Zhang et al."A dissolving and glucose-responsive insulin-releasing microneedle patch for type 1 diabetes therapy."J Mater Chem B. 2021 Jan;9(3):648-657 25. [IF=6.868] Zhu Shiming et al."Insulin/IGF signaling and TORC1 promote vitellogenesis via inducing juvenile hormone biosynthesis in the American cockroach."Development. 2020 Oct;147(20): 24. [IF=7.328] Mingxin Wu et al."Assisted 3D printing of microneedle patches for minimally invasive glucose control in diabetes."Mat Sci Eng C-Mater. 2020 Dec;117:111299 23. [IF=7.514] Chi Zhang et al."Identification of soybean peptides and their effect on the growth and metabolism of Limosilactobacillus reuteri LR08."Food Chem. 2022 Feb;369:130923 22. [IF=7.514] Lu Han et al."Co-delivery of insulin and quercetin in W/O/W double emulsions stabilized by different hydrophilic emulsifiers."Food Chem. 2022 Feb;369:130918 21. [IF=10.435] Zhang Yujie et al."High drug-loading gold nanoclusters for responsive glucose control in type 1 diabetes."J Nanobiotechnol. 2019 Dec;17(1):1-11 20. [IF=1.851] Wei Gao et al."Mitochondrial transcription factor A contributes to cisplatin resistance in patients with estrogen receptor‑positive breast cancer."Mol Med Rep. 2016 Dec;14(6):5304-5310 19. [IF=2.352] Rong-zu Nie et al."Comparison of disaggregative effect of A-type EGCG dimer and EGCG monomer on the preformed bovine insulin amyloid fibrils."Biophys Chem. 2017 Nov;230:1 18. [IF=2.509] Farzana Abbasi et al."Effects of feeding corn naturally contaminated with aflatoxin on growth performance, apparent ileal digestibility, serum hormones levels and gene expression of Na+, K+-ATPase in ducklings."Asian Austral J Anim. 2018 Jan; 31(1): 91–97 17. [IF=2.877] Tao Wu et al."Timing of glucocorticoid administration determines severity of lipid metabolism and behavioral effects in rats."Chronobiol Int. 2017;34(1):78-92 16. [IF=2.932] Jihui Wang et al."Linoelaidic acid enhances adipogenic differentiation in adipose tissue-derived stromal cells through suppression of Wnt/β-catenin signaling pathway in vitro."Prostag Leukotr Ess. 2016 Jul;110:1 15. [IF=3.04] Z. Chen et al."Impaired learning and memory in rats induced by a high‐fat diet: Involvement with the imbalance of nesfatin‐1 abundance and copine 6 expression."J Neuroendocrinol. 2017 Apr;29(4): 14. [IF=3.205] Dandan Lan et al."Preparation of a hydroxyethyl-based monolithic column and its application in the isolation of intact proteins from complex bio-samples."J Chromatogr B. 2019 Jan;1104:89 13. [IF=4.079] Rong-zu Nie et al."A-type dimeric epigallocatechin-3-gallate (EGCG) is a more potent inhibitor against the formation of insulin amyloid fibril than EGCG monomer."Biochimie. 2016 Jun;125:204 12. [IF=5.88] Ruixue Yin et al."Engineering synthetic artificial pancreas using chitosan hydrogels integrated with glucose-responsive microspheres for insulin delivery."Mat Sci Eng C-Mater. 2019 Mar;96:374 11. [IF=6.057] Shaoai Sun et al."Preparation and retention mechanism exploration of mesostructured cellular foam silica as stationary phase for high performance liquid chromatography."Talanta. 2016 Mar;149:187 10. [IF=6.953] Meirong Bai et al."Regulated basal and bolus insulin release from glucose-responsive core-shell microspheres based on concanavalin A-sugar affinity."Int J Biol Macromol. 2018 Jul;113:889 9. [IF=7.79] Yujie Zhang et al."Gold nanoclusters for controlled insulin release and glucose regulation in diabetes."Nanoscale. 2019 Mar;11(13):6471-6479 8. [IF=10.618] Xiuhua Sun et al."Creation of antifouling microarrays by photopolymerization of zwitterionic compounds for protein assay and cell patterning."Biosens Bioelectron. 2018 Apr;102:63 7. Zhang, Yujie, et al. "Glucose-Responsive Gold Nanocluster-Loaded Microneedle Patch for Type 1 Diabetes Therapy." ACS Applied Bio Materials 3.12 (2020): 8640-8649.https://doi.org/10.1021/acsabm.0c01042 6. Wu, Mingxin, et al. "Assisted 3D printing of microneedle patches for minimally invasive glucose control in diabetes." Materials Science and Engineering: C 117 (2020): 111299.https://doi.org/10.1016/j.msec.2020.111299 5. 李思维,卫倩倩,宋宵,张珩,焦韵苹.党参多糖的抗氧化及降糖活性研究[J].临床医学研究与实践,2020,5(32):8-11. 4. 胡等慧,王秀丽,任蕾蕾.胰岛素超多孔水凝胶控释制剂的制备及其检测[J].药学实践杂志,2021,39(01):44-48+76. 3. 庞延,卢健棋,朱智德,王庆高,温志浩,梁逸强,林浩,唐梅玲,许志亮.稳心颗粒对心肌梗死大鼠模型心肌脂肪化及E6AP、C/EBPα表达影响[J].中国中医基础医学杂志,2021,27(01):61-64. 2. 罗明志, 余培丽, 金阳,等. 血根碱对大鼠气道平滑肌细胞生物力学特性的影响[J]. 生物医学工程学杂志, 2018, v.35(04):89-97. 1. 张靖伟, 姚英俊, 梁媛,等. 油酸对C57/BL6J小鼠脂肪干细胞体外成脂分化的影响[J]. 大连工业大学学报, 2017(5).