• 介绍：

  Cyclophosphamide Monohydrate是一种氮芥类烷化剂，使烷基连接到DNA的鸟嘌呤碱基。与DNA交联，造成DNA链断裂，引起突变。具有细胞毒性作用。

• 体外研究：Cyclophosphamide (CY)是一种化学治疗剂，对免疫系统具有剂量依赖性双重作用。Cyclophosphamide治疗增强细胞凋亡，并降低调控T细胞的稳态增殖。Cyclophosphamide下调GITR和FoxP3的表达，其涉及T(REGs)的抑制活性。Cyclophosphamide增加原代人肝细胞培养物中CYP3A4，CYP2C8，和 CYP2C9蛋白水平，从而提高培养的肝细胞中它们自身的4-羟基化比率。代谢活化存在下，Cyclophosphamide使Salmonella tryphimurium的碱基对取代菌株产生突变，但是在 E. coli显色测试中显示为阴性。代谢活化存在下，Cyclophosphamide能够使各种人工培养的细胞中产生基因突变，染色体畸变，微核和姐妹染色单体互换，并且代谢活化不存在时，会产生姐妹染色单体互换。

• 体内研究：Cyclophosphamide会使大鼠，小鼠和中国仓鼠体内产生染色体损伤和微核，并且在小鼠斑点试验和Muta小鼠转基因lacZ构建体中产生基因突变。Cyclophosphamide，以确定的顺序加入到GM-CSF-分泌的，neu-表达的全细胞疫苗中，能够增强疫苗的潜在作用以延缓neu转基因小鼠体内的肿瘤生长。Cyclophosphamide通过增强疫苗的功效，而不是通过对癌细胞的直接细胞溶解作用发挥它的作用。

• 熔点： 49-53℃

• 沸点： 110℃

• 外观： 白色或类白色结晶或结晶性粉末

• 溶解性： 10mg/ml  水（溶液状态不稳定，需要现配现用）。

• 敏感性： 对热,光,空气敏感

• 储存条件： 2-8℃

• 用途： 本品仅供科研，不得用于其它用途。

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 51. [4.4] Qu Minmin et al."Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells."Frontiers in Pharmacology.2024 Jun;15:

• 50. [5.7] Xuejiao Wang et al."A Hirsutella sinensis Alcohol Extract Exerts Bidirectional Immunoregulatory Effects by Regulating Macrophage Polarization."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2024;XXXX(XXX):XXX-XXX

• 49. [4.3] Qinbing Xue et al."Lycorine (Lycoris radiata)—a unique natural medicine on breast cancer."JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2024 Aug;28(16):e70032

• 48. [2.9] Yuhao Meng et al."Therapeutic effects of curculigoside on cyclophosphamide-induced premature ovarian failure in mice."CLIMACTERIC.

• 47. [IF=8.2] Qinbing Xue et al."Structural characterization and immune-enhancing effects of a novel polysaccharide extracted from Sargassum fusiforme."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES".2024 May;:132497

• 46. [IF=1.8] Ruxin Wang et al."Network Pharmacology and In Vivo Validation to Explore the Potential Active Ingredients and Mechanisms of Ziyin Buyang Formula in Diminished Ovarian Reserve."Natural Product Communications.10.1177/1934578X241242281

• 45. [IF=6.3] Ping Tang et al."Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury in mice."Current Research in Food Science".2024 Jan;8:100734

• 44. [IF=6.6] Qiao Qinggang et al."Structure and immunostimulating activity of polysaccharides derived from the roots and leaves of dandelion."Chemical and Biological Technologies in Agriculture".2024 Dec;11(1):1-18

• 43. [IF=5.2] Zheng Mei et al."Synergistic effects of ceftazidime/avibactam combined with meropenem in a murine model of infection with KPC-producing Klebsiella pneumoniae."JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY".2024 Mar;:

• 42. [IF=2] Weimei Zhou et al."LIPUS combined with TFSC alleviates premature ovarian failure by promoting autophagy and inhibiting apoptosis."GYNECOLOGICAL ENDOCRINOLOGY.2023;39(1):Article: 2258422

• 41. [IF=4.6] Yi Cheng et al."Effects of Solid Fermentation on Polygonatum cyrtonema Polysaccharides: Isolation, Characterization and Bioactivities."MOLECULES.2023 Jan;28(14):5498

• 40. [IF=2.7] Xiaoyin Meng et al."Hydrogen-rich water treatment targets RT1-Db1 and RT1-Bb to alleviate premature ovarian failure in rats."PeerJ.2023 Jun;11:e15564

• 39. [IF=6.4] Zhang Hongyin et al."Immunomodulatory activity of semen Ziziphi Spinosae protein: a potential plant protein functional food raw material."npj Science of Food.2023 Jun;7(1):1-13

• 38. [IF=3.318] Peng Qi et al."Simultaneous quantification of pirarubicin, doxorubicin, cyclophosphamide, and vincristine in human plasma of patients with non-Hodgkin's lymphoma by LC–MS/MS method."JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND

• 37. [9.043] Yi Zhang et al."Flufenamic Acid, a Promising Agent for the Sensitization of Colistin-Resistant Gram-Negative Bacteria to Colistin."Microbiology Spectrum.

• 36. [11.504] Zhengxin Shan et al."Insight into the structural and immunomodulatory relationships of polysaccharides from Dendrobium officinale-an in vivo study."FOOD HYDROCOLLOIDS.2023 May;139:108560

• 35. [4.014] Min He et al."Effect of Rubia cordifolia L. processed Terminalia chebula Retz polysaccharide on the histological structure and apoptosis in the spleen in immunosuppressed Chinese yellow quail."POULTRY SCIENCE.2022 Dec;:102416

• 34. [IF=4.219] Yiqun Li et al."Emodin-8-O-β-D-glucopyranoside, a natural hydroxyanthraquinone glycoside from plant, suppresses cancer cell proliferation via p21-CDKs-Rb axis."Toxicol Appl Pharm. 2022 Mar;438:115909

• 33. [IF=2.863] Jian Zhang et al."Immunomodulatory effects of selenium-enriched peptides from soybean in cyclophosphamide-induced immunosuppressed mice."Food Sci Nutr. 2021 Nov;9(11):6322-6334

• 32. [IF=4.411] Feng Liu et al."Immunomodulatory Activity of Carboxymethyl Pachymaran on Immunosuppressed Mice Induced by Cyclophosphamide."Molecules. 2021 Jan;26(19):5733

• 31. [IF=5.64] Yan Yong et al."Exogenous Citrulline and Glutamine Contribute to Reverse the Resistance of Salmonella to Apramycin."Front Microbiol. 2021; 12: 759170

• 30. [IF=7.514] Tingting Ma et al."Effects of co-fermented collagen peptide-jackfruit juice on the immune response and gut microbiota in immunosuppressed mice."Food Chem. 2021 Dec;365:130487

• 29. [IF=9.229] Sheng Xu et al."Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression."Acs Appl Mater Inter. 2021;13(38):45175–45190

• 28. [IF=4.759] Li Zhou et al."Independent or integrative processing approach of metabolite datasets from different biospecimens potentially affects metabolic pathway recognition in metabolomics."J Chromatogr A. 2019 Feb;1587:146

• 27. [IF=5.79] Yu Yang et al."Novel partners with colistin to increase its in vivo therapeutic effectiveness and prevent the occurrence of colistin resistance in NDM- and MCR-co-producing Escherichia coli in a murine infection model."J Antimicrob Chemoth. 2019 Jan;74(1)

• 26. 牛佳卉,袁静,魏然,张晓富,张慧芳,贾金玉,赵文.红枣多糖对小鼠肠道免疫屏障的保护作用及机制研究[J].食品工业科技,2021,42(04):295-300+306.

• 25. 张林,章亮,肖圣雄,姚飞虹,张辉.钕水杨酸硫代脯氨酸配合物对小鼠的LD_(50)和骨髓细胞微核实验研究[J].广东化工,2020,47(16):63-64.

• 24. 艾丹,常若葵,张斌,于玮玮,王远宏.美极梅奇酵母T-2灌胃对小鼠的毒性作用[J].食品研究与开发,2020,41(22):1-6.

• 23. 王丹阳,朱晓庆,谷新利,王蒙蒙,孙国结,武梦丽,王虹,丁艳,罗燕,连科迅.硒化甘草多糖联合抗生素体外抑菌作用及体内免疫调节作用研究[J].中国兽医科学,2021,51(01):126-134.

• 22. 罗亮,李欣蔓,马靖宜,林居纯,符华林,顾健,何黎黎,袁志翔.白芦笋鲜汁及残渣醇提物不同极性部位的免疫活性研究[J].中南药学,2021,19(03):397-401.

• 21. 李莉,刘潇祎,苏刘艳,蒋昕,张祎,王睿睿.屏边三七提取物协同氟康唑抗耐药白念珠菌的作用及机制研究[J].中华中医药学刊,2021,39(01):51-57+269-273.

• 20. 李莹雪,王锐银,包永明.芹菜素与丹参酮Ⅱ_A的协同抗肿瘤作用及机制[J].中草药,2020,51(22):5788-5797.

• 19. 何巧梅,於芳芳,孙希,丁晓丹,袁秀杰,张岩,宋献民.异基因骨髓移植混合嵌合体小鼠模型的构建及影响因素分析[J].中国实验血液学杂志,2021,29(02):603-609.

• 18. 马晓平, 杨秋霞, 俞演,等. 大熊猫源枝孢样枝孢霉野生株(Z20)与突变株(Zt)部分生物学特性及药敏试验比较[J]. 浙江农业学报, 2018(8):1328-1335.

• 17. 伍璀 牛瑞斌 叶枫 等. 丙泊酚下调miR-93-5p表达对乳腺癌MDA-MB-231细胞增殖 侵袭的影响[J]. 中国药师 2020 v.23(06):48-53.

• 16. 郝李娟, 李瑞娟, 习南,等. 黄芪多糖对血虚模型鸡外周血的影响[J]. 中国畜牧兽医, 2014, 41(4):255-257.

• 15. 卢燕, 李亚菲, 肖倩雯,等. 马波沙星在多杀性巴氏杆菌感染的小鼠体内的药动学研究[J]. 中国兽医科学, 2016(9):1183-1188.

• 14. 李晓, 高慧婕, 朱桐林,等. 阿胶对环磷酰胺所致免疫抑制小鼠的免疫保护作用[J]. 济宁医学院学报, 2019, 42(6):385-389.

• 13. 施强, 郑勇斌, 睢凤英,等. 尼古丁对小鼠骨髓细胞微核影响的实验研究[J]. 中国美容医学杂志, 2011, 20(0z6):118,120.

• 12. 陈丽娥, 孙盛, 俞赟霞,等. 西北传统食品中乳酸菌的分离及提高免疫力菌株的筛选[J]. 中国乳品工业, 2019(10).

• 11. 胡嘉宇, 常若葵, 刘柏君,等. 葡萄球菌S-35对小鼠的毒性作用[J]. 农药, 2020, v.59(05):38-42.

• 10. 王建舫, 贾梦然, 胡艳姣,等. 芪参口服液对免疫功能低下小鼠的保护作用[J]. 中国农学通报, 2013(11):24-28.

• 9. 李培宁,江漪,陈秀娟,刘香梅,庞增雄,黄宇锋.致畸试验中3种常用阳性对照物的效果比较[J].癌变·畸变·突变,2017,29(03):235-240.

• 8. 陈秀娟,江漪,李敏,李培宁,孙侠,陈梓灵,丘智峰,黄宇锋.用吖啶橙-流式细胞仪技术检测间苯二胺、对苯二胺诱导的小鼠骨髓细胞微核率[J].实验动物与比较医学,2019,39(03):231-235.

• 7. 陈龙云, 周艳艳, 徐安莉,等. 槲皮苷对免疫功能低下小鼠的免疫调节作用[J]. 中国免疫学杂志, 2019(19).

• 6. 张维彬, 樊丹采, 张敏,等. 桔梗水提液及其主要成分桔梗皂苷D对环磷酰胺药代动力学的影响[J]. 中药材, 2016, 39(011):2633-2635.

• 5. 刘汉斌, 2], 彭娇娇,等. 强鸡散对免疫抑制小鼠脾转录因子GATA-3和T-bet表达量的影响[J]. 广东农业科学, 2014(19).

• 4. 曹洛云, 李天娇, 孟宪生,等. 山豆根生物碱对DEN诱发肝癌大鼠的作用及机制研究[J]. 中国现代应用药学, 2018, 035(003):370-374.

• 3. 李淑艳, 王玉华, 吴东兴,等. 大鼠急性肠炎模型制备方法的建立与探讨[J]. 中成药, 2018, 40(002):444-446.

• 2. 周小露, 陈崇俊, 冉莉莎,等. 复合茯砖袋泡茶的配方优化及安全性评价[J]. 现代食品科技, 2020, v.36;No.248(04):216-225.

• 1. 聂露霞,廖水亨,苑述刚,马少丹.基于免疫力低下模型小鼠的樟芝升白汤肝肾毒性研究[J].中医临床研究,2016,8(23):8-11.

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *