| 产品描述： | Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells. |
| 靶点： |
5-HT2A Receptor;5-HT2C Receptor;DopamineReceptor;5-HTReceptor;AdrenergicReceptor;Autophagy |
| 体内研究： |
Sertindole (oral gavage; 10 mg/kg; once daily; 12 d) shows anti-tumor activity in vivo |
| 参考文献： |
1. David Murdoch, et al. Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55. 2. Wei Zhang, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018 Oct 25;8(1):15753. 3. Mario F Juruena, et al. Sertindole in the management of schizophrenia. J Cent Nerv Syst Dis. 2011 May 17;3:75-85. |
| 溶解性： |
DMSO : 25 mg/mL (56.70 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.268 ml |
11.339 ml |
22.679 ml |
| 5 mM |
0.454 ml |
2.268 ml |
4.536 ml |
| 10 mM |
0.227 ml |
1.134 ml |
2.268 ml |
| 50 mM |
0.045 ml |
0.227 ml |
0.454 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京