| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80128-10mg促销 |
≥98% | ￥106.00 ￥95.00 |
9 | 2 | 4 | - |
|
S80128-50mg促销 |
≥98% | ￥225.00 ￥202.00 |
1 | 4 | - | - |
|
S80128-250mg促销 |
≥98% | ￥896.00 ￥806.00 |
货期：3-5天 | 1 | 2 | - |
|
| 产品描述： | Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter. | ||||||||||||||||||||
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| 靶点： | Potassium Channel;PotassiumChannel | ||||||||||||||||||||
| 体内研究： | Dofetilide (100 mg/kg, i.v.) does not suppress automaticity arrhythmias induced by two-stage coronary ligation and epinephrine or the coronary ligation and reperfusion arrhythmias, but suppresses the reentry arrhythmia induced by PES in dogs with old myocardial infarction (MI). Dofetilide also shows antiarrhythmic effect in some dogs with digitalis arrhythmia. Dofetilide increases QT interval and shows negative chronotropic effect like that of other class III drugs, but is different in antiarrhythmic profiles from those of other class III agents such as D-sotalol, E-4031, and MS-551 in that it does not prevent the occurrence of ventricular fibrillation (VF) immediately after coronary reperfusion and has some antiarrhythmic effects on digitalis arrhythmia. Dofetilide causes increased resorptions and the same stage-dependent malformations in Sprague-Dawley rats. | ||||||||||||||||||||
| 参考文献： | 1. Webster WS, et al. Teratology, 1996, 53(3), 168-175. 2. Bauer A, et al. J Cardiovasc Pharmacol, 2002, 39(3), 460-467. 3. Kiehn J, et al. Circulation, 1996, 94(10), 2572-2579. 4. Kiehn J, et al. J Cardiovasc Pharmacol, 1994, 24(4), 566-572. 5. Chen J, et al. J Cardiovasc Pharmacol, 1996, 28(4), 576-584. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | RT | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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