品牌：源叶(MedMol)

产品编号：S80189 一键复制产品信息

CAS号：122547-49-3

分子式：C₁₂H₁₄NO₅S.Na

分子量：307.298

别名：法罗培南钠;法罗培南;(+)-(5R,6S)-6-[(R)-1-羟基乙基]-7-氧代-3-[(R)-2-四氢呋喃基]-4-硫杂-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸钠;法罗培南(钠)(二倍半水合物);(+)-(5R,6S)-6-[(R)-1-羟基乙基]-7-氧代-3-[(R)-2-四氢呋喃基]-4-硫杂-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸钠;法罗培南钠;(5r,6s)-6-(

货号	规格	价格	上海	北京	武汉	南京
S80189-5mg	≥98%	￥210.00 S80189-5mg ￥210.00 现货	400 >10	-	-	-
S80189-10mg	≥98%	￥290.00 S80189-10mg ￥290.00 现货	200 >10	-	-	-
S80189-25mg	≥98%	￥520.00 S80189-25mg ￥520.00 现货	80 >10	-	-	-
S80189-50mg	≥98%	￥700.00 S80189-50mg ￥700.00 现货	40 >10	-	-	-
S80189-100mg	≥98%	￥970.00 S80189-100mg ￥970.00 现货	20 >10	-	-	-

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产品介绍

Faropenem sodium是具有口服活性的β-内酰胺抗生素，用于研究治疗肺结核和社区获得性肺炎的试验中。

产品描述：

Faropenem sodium是具有口服活性的β-内酰胺抗生素，用于研究治疗肺结核和社区获得性肺炎的试验中。

靶点：

Antibacterial;Antibiotic

细胞实验：

Cell lines: RAW macrophages Concentrations: 7, 28, or 56 μg/ml Incubation Time: -- Method: RAW macrophages were grown in Dulbecco modified Eagle medium containing l-glutamine and sodium pyruvate (PAA Laboratories) supplemented with 10% fetal bovine serum. About 2.5 × 104 cells were seeded into each well of a 48-well plate and were infected with green fluorescent protein (GFP)-expressing M. tuberculosis (MTB_NDT1) at a multiplicity of infection (MOI) of 10:1 for 4 h. After infection, the monolayers were washed three times with fresh medium to remove nonadherent bacteria and then exposed to fresh medium with or without isoniazid (0.75 μg/ml), faropenem (7, 28, or 56 μg/ml), or meropenem (5, 25, or 50 μg/ml) plus clavulanate (2.5 μg/ml). Medium (containing antibiotics) was changed every 24 h. At various time points, macrophages were washed once with 1× PBS and then lysed using 0.5% Triton X-100. The macrophage lysates were diluted in PBS containing 0.05% Tween 80, serial dilutions were plated on 7H10 agar, a

动物实验：

Animal Models: Adult female C57BL/6J mice Dosages: 500 mg/kg Administration: oral

参考文献：

1. Dhar N, et al. Antimicrob Agents Chemother. 2015, 59(2):1308-19.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.254 ml	16.271 ml	32.542 ml
5 mM	0.651 ml	3.254 ml	6.508 ml
10 mM	0.325 ml	1.627 ml	3.254 ml
50 mM	0.065 ml	0.325 ml	0.651 ml

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参考文献

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