| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80189-5mg |
≥98% | ￥190.00 | >10 | - | - | - |
|
S80189-10mg |
≥98% | ￥290.00 | >10 | - | - | - |
|
S80189-25mg |
≥98% | ￥520.00 | >10 | - | - | - |
|
S80189-50mg |
≥98% | ￥700.00 | >10 | - | - | - |
|
S80189-100mg |
≥98% | ￥970.00 | >10 | - | - | - |
|
| 产品描述： | Faropenem sodium是具有口服活性的β-内酰胺抗生素，用于研究治疗肺结核和社区获得性肺炎的试验中。 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Antibacterial;Antibiotic | ||||||||||||||||||||
| 体内研究： | Faropenem (500 mg/kg，口服，感染后第 1 至 7 天) sodium 可降低小鼠急性结核病感染模型中的细菌 (结核分枝杆菌) 负荷。 Faropenem (10-80 mg/kg/天，腹腔注射，感染后 24 h，间隔 4、6 和 12 h，共 14 天) sodium在小鼠暴露后预防吸入模型中表现出对抗炭疽杆菌的高水平活性。 |
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| 细胞实验： | Cell lines: RAW macrophages Concentrations: 7, 28, or 56 μg/ml Incubation Time: -- Method: RAW macrophages were grown in Dulbecco modified Eagle medium containing l-glutamine and sodium pyruvate (PAA Laboratories) supplemented with 10% fetal bovine serum. About 2.5 × 104 cells were seeded into each well of a 48-well plate and were infected with green fluorescent protein (GFP)-expressing M. tuberculosis (MTB_NDT1) at a multiplicity of infection (MOI) of 10:1 for 4 h. After infection, the monolayers were washed three times with fresh medium to remove nonadherent bacteria and then exposed to fresh medium with or without isoniazid (0.75 μg/ml), faropenem (7, 28, or 56 μg/ml), or meropenem (5, 25, or 50 μg/ml) plus clavulanate (2.5 μg/ml). Medium (containing antibiotics) was changed every 24 h. At various time points, macrophages were washed once with 1× PBS and then lysed using 0.5% Triton X-100. The macrophage lysates were diluted in PBS containing 0.05% Tween 80, serial dilutions were plated on 7H10 agar, a | ||||||||||||||||||||
| 动物实验： | Animal Models: Adult female C57BL/6J mice Dosages: 500 mg/kg Administration: oral | ||||||||||||||||||||
| 参考文献： | 1. Dhar N, et al. Antimicrob Agents Chemother. 2015, 59(2):1308-19. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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