品牌：源叶(MedMol)

产品编号：S80223 一键复制产品信息

CAS号：124937-51-5

分子式：C₂₂H₃₁NO

分子量：325.488

别名：托特罗定;6--2-[3-(二异丙胺基)-1-苯丙基]-4-甲基苯酚;(R)-2-[3-(二异丙胺基)-1-苯丙基]-4-甲基苯酚;托特罗定;-2-[3-[二(1-甲基乙基)氨基]-1-苯丙基]-4-甲基苯酚;托特罗定-D14;托特罗定(R)-2-[3-(二异丙胺基)-1-苯丙基]-4-甲基苯酚;DETRUSITOL;DETROL;(+)-(R)-2-[A-[2-(DIISOPROPYLAMINO

货号	规格	价格	上海	北京	珠海	武汉	购买数量
S80223-5mg	≥94%	￥660.00 S80223-5mg ￥660.00 3-5天	0 货期：3-5天	-	-	-
S80223-10mg	≥94%	￥990.00 S80223-10mg ￥990.00 3-5天	0 货期：3-5天	-	-	-

货号

规格

价格

上海

北京

珠海

武汉

购买数量

S80223-5mg

≥94%

￥660.00

货期：3-5天

S80223-10mg

≥94%

￥990.00

货期：3-5天

产品描述：

Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value: Target: mAChR in vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors. in vivo: Tolterodine was extensively metabolized in vivo. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased

靶点：

mAChR

参考文献：

1. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7. 2. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35. 3. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.072 ml	15.362 ml	30.723 ml
5 mM	0.614 ml	3.072 ml	6.145 ml
10 mM	0.307 ml	1.536 ml	3.072 ml
50 mM	0.061 ml	0.307 ml	0.614 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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