S80363 |
RESIQUIMOD |
| 源叶(MedMol) | 98% |
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- 产品描述： Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.
- 靶点： TLR7;TLR8
- 体内研究： Resiquimod (R-848) (50 μg/bird, i.m. route) significantly up-regulates the expression of IFN-α, IFN-β, IFN-γ, IL-1β, IL-4, iNOS and MHC-II genes in SPF chicken
- 参考文献：
1. Sachan S, et al. Adjuvant potential of resiquimod with inactivated Newcastle disease vaccine and its mechanism of action in chicken. Vaccine. 2015 Aug 26;33(36):4526-32. 2. Brugnolo F, et al. The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells. J Allergy Clin Immunol. 2003 Feb;111(2):380-8. 3. Zhou ZX, et al. Immune effects of R848: evidences that suggest an essential role of TLR7/8-induced, Myd88- and NF-κB-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus). Dev Comp Immunol. 2015 Mar;49(1):113-20.
- 溶解性： DMF : 50 mg/mL (159.04 mM; Need ultrasonic) DMSO : ≥ 30 mg/mL (95.43 mM) Methanol : 25 mg/mL (79.52 mM; Need ultrasonic) H2O : 0.1 mg/mL (0.32 mM; Need ultrasonic)
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 3.181 ml 15.904 ml 31.808 ml 5 mM 0.636 ml 3.181 ml 6.362 ml 10 mM 0.318 ml 1.59 ml 3.181 ml 50 mM 0.064 ml 0.318 ml 0.636 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
