货号	规格	价格	上海	北京	珠海	武汉
S80369-1mg	99.31%	￥120.00 S80369-1mg ￥120.00 现货	8 8	-	-	-
S80369-2mg	99.31%	￥160.00 S80369-2mg ￥160.00 现货	4 4	-	-	-
S80369-5mg	99.31%	￥200.00 S80369-5mg ￥200.00 现货	1 1	-	-	-
S80369-10mg	99.31%	￥280.00 S80369-10mg ￥280.00 现货	2 2	-	-	-
S80369-25mg	≥98%	￥480.00 S80369-25mg ￥480.00 2-3天	0 货期：2-3天	-	-	-
S80369-50mg	99.31%	￥800.00 S80369-50mg ￥800.00 现货	3 3	-	-	-
S80369-100mg	≥98%	￥1500.00 S80369-100mg ￥1500.00 2-3天	0 货期：2-3天	-	-	-

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产品描述：

MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease

靶点：

Insulin Receptor;Mitochondrial Metabolism;IGF-1R;MitochondrialMetabolism

体外研究：

MSDC 0160 (Mitoglitazone; 1-50 µM; for 24 hours) significantly decreases phosphorylation of mTOR at 20 and 50 µM. MSDC 0160 acts as insulin sensitizers without activating PPARγ. MSDC 0160 (10 μM; pretreatment 1 hour) prevents the MPP+ (10 μM)-induced loss of both tyrosine hydroxylase (TH)-immunoreactive differentiated Lund human mesencephalic (LUHMES) cells. MSDC 0160 (10 or 100 μM) prevents the loss of GFP-fluorescent dopaminergic neurons induced by MPP+ (0.75 mM) in nematodes. MSDC 0160 (10-20 μM) in conbination with IGF-1 prevents the loss of insulin content and maintains insulin secretion. MSDC 0160 (1-50 μM) treatment maintains human β-cell phenotype. Western Blot Analysis Cell Line: Human islets Concentration: 1, 10, 20, 50 µM Incubation Time: For 24 hours Result: Significantly decreased Phosphorylation of mTOR at 20 and 50 µM.

体内研究：

MSDC 0160 (Mitoglitazone; 30 mg/kg; oral gavage; daily; for 7 days) improves locomotor behavior, increases survival of nigral dopaminergic neurons, boosts striatal dopamine levels, and reduces neuroinflammation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Animal Model: Ten- to 12-week-old male C57BL/6J mice weighing 24 to 28 g Dosage: 30 mg/kg Administration: Oral gavage; daily; for 7 days Result: Improved locomotor behavior, increased survival of nigral dopaminergic neurons, boosted striatal dopamine levels, and reduced neuroinflammation.

参考文献：

1. Rohatgi N, et al. Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PLoS One. 2013 May 1;8(5):e62012. 2. Ghosh A, et al. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration inexperimental models of Parkinson's disease. Sci Transl Med. 2016 Dec 7;8(368):368ra174.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.7 ml	13.498 ml	26.996 ml
5 mM	0.54 ml	2.7 ml	5.399 ml
10 mM	0.27 ml	1.35 ml	2.7 ml
50 mM	0.054 ml	0.27 ml	0.54 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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