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• 产品描述： Trapidil is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease.

• 靶点： PDGFR;PDE

• 体内研究： Trapidil is an antiplatelet drug with specific platelet-derived growth factor antagonism and antiproliferative effects in the rat and rabbit models after balloon angioplasty. Trapidil had a potent inhibitory effect on osteoclast formation and bone resorption induced by interleukin-1 in an animal model. No abnormal symptoms, such as changes in body weight, diarrhea, high fever, and convulsion, were observed after intraperitoneal injections of trapidil

• 细胞实验： Cell viability was determined by Trypan blue dye exclusion test and LDH assay. Supernatants, collected from cells seeded in serum-free medium and exposed to the different mitogens and drugs tested, were centrifuged and LDH concentration determined. Supernatants obtained from sonicated cells were used as a positive control. Furthermore, to definitely exclude a cytotoxic effect of Trapidil on human MC, cells incubated for four days with and without the drug were challenged with fresh medium containing 10% FBS, and cell proliferation evaluated. (Only for Reference)

• 参考文献：
  1.Gesualdo L, et al. Kidney Int. 1994, 46(4):1002-9. 2.Kim SD, et al. Biochem Pharmacol. 2013, 86(6):782-90. 3.Maresta A, et al. Circulation. 1994, 90(6):2710-5.

• 溶解性： Ethanol:39  mg/mL  (190  mM)    DMSO:39  mg/mL  (190  mM)    H2O:38  mg/mL  (185.1  mM)

• 保存条件： -20℃,避光

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	4.872 ml	24.359 ml	48.719 ml
  5 mM	0.974 ml	4.872 ml	9.744 ml
  10 mM	0.487 ml	2.436 ml	4.872 ml
  50 mM	0.097 ml	0.487 ml	0.974 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *