S80448 |
PD1-PDL1 inhibitor 1 |
| 源叶(MedMol) | 99% |
- 提示：详情请下载说明书。
- 产品描述： BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1)是一种PD-1/PD-L1相互作用的小分子化合物抑制剂，IC50为6 nM
- 靶点： PD-1/PD-L1 interaction(Cell-free assay):0.006 μM
- 体外研究： PD-1/PD-L1 inhibitor 1 causes half-reduced cell viability at lower concentrations in triple-negative breast cancer (TNBC), activates ERK in MDA-MB-231 and MCF7, significantly increases IL-8 expression in MDA-MB-231 and HCC1806 when administrated in combination with ERK1/2 inhibitor, also potently downregulates the IL-8 expression to its half amount in MDA-MB-231
- 体内研究： PD-1/PD-L1 inhibitor 1 combined with Jiedu Sangen Decoction (JSD) remarkably inhibits and reverses epithelial-mesenchymal transition (EMT) via PI3K/AKT signaling pathway
- 细胞实验： Cell lines: MDA-MB-231 cells, HCC1937 cells, HCC1806 cells, MCF7 cells Concentrations: -- Incubation Time: 72 h Method: Cell proliferation is determined by the MTS assay. A total of 1-2×103 cells are plated in 100 μl medium in each well of a 96-well plate. After 24 h, PD-1/PD-L1 inhibitor 1 and ERK1/2 inhibitor are diluted to the desired concentrations in test medium (DMEM containing 1% fetal bovine serum) and added as single or as combined treatment in triplicate for 72 h.
- 动物实验： Animal Models: Male specific pathogen free BALB/c mice of hepatic metastatic colorectal cancer (CRC) model Dosages: 100 µg Administration: i.p.
- 参考文献：
1. WO/2015/034820, COMPOUNDS USEFUL AS IMMUNOMODULATORS. 2. Bräutigam K, et al. Inhibitors of PD-1/PD-L1 and ERK1/2 impede the proliferation of receptor positive and triple-negative breast cancer cell lines. J Cancer Res Clin Oncol. 2021;147(10):2923-2933. 3. Shan, Feiyu et al. Inhibition to Epithelial-Mesenchymal Transition and Metastatic Potential In Colorectal Cancer Cell By Combination of Traditional Chinese Medicine Formulation Jiedu Sangen Decoction and PD-L1 Inhibitor. Integrative cancer therapies vol. 19 (2020): 1534735420972486.
- 溶解性： Soluble in DMSO、Ethanol、H2O
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.103 ml 10.514 ml 21.027 ml 5 mM 0.421 ml 2.103 ml 4.205 ml 10 mM 0.21 ml 1.051 ml 2.103 ml 50 mM 0.042 ml 0.21 ml 0.421 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
