| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80449-5mg |
99.90% | ￥580.00 | 6 | - | - | - |
|
S80449-10mg |
99.90% | ￥950.00 | 9 | - | - | - |
|
S80449-25mg |
99.90% | ￥1860.00 | 3 | - | - | - |
|
S80449-100mg |
99.90% | ￥4200.00 | 1 | - | - | - |
|
| 产品描述： | BMS202 (PD-1/PD-L1 inhibitor 2)是一种抑制PD-1/PD-L1相互作用的小分子化合物，IC50为18 nM | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | PD-1/PD-L1 interaction(Cell-free assay):0.018 μM;Apoptosis;PD-1/PD-L1 | ||||||||||||||||||||
| 体外研究： | BMS-202 inhibits PD-1/PD-L1 binding in SCC-3 and Jurkat cells with IC50 of 15 μM and 10 μM, respectively. | ||||||||||||||||||||
| 体内研究： | BMS-202 treatment shows a clear antitumor effect compared with the controls, in humanized MHC- dKO NOG mice. | ||||||||||||||||||||
| 细胞实验： | Cell lines: SCC-3 and Jurkat cells Concentrations: IC50 of 15 μM and 10 μM Incubation Time: 4 days Method: Cells were treated with various concentrations of drug for 4 days. | ||||||||||||||||||||
| 动物实验： | Animal Models: NOG-dKO mice Dosages: 20 mg/kg Administration: i.p. | ||||||||||||||||||||
| 参考文献： | 1. (WO2015034820), COMPOUNDS USEFUL AS IMMUNOMODULATORS. 2. Krzysztof M. Zak, et al. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget. 2016, 7(21): 30323–30335. 3. Ashizawa T, et al. Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse. Biomed Res. 2019;40(6):243-250. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
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营业执照(三证合一)
北京