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• 产品描述： Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)

• 靶点： Ki: 4.5 nM (thrombin)

• 体内研究： Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model

• 参考文献：
  1. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62. 2. Hauel NH, et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem. 2002 Apr 25;45(9):1757-66. 3. Wienen W, et al. Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats. Thromb Haemost. 2007 Aug;98(2):333-8.

• 溶解性： 0.1  M  HCL  :  12.5  mg/mL  (26.51  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (insoluble)    DMSO  :  <  1  mg/mL  (insoluble  or  slightly  soluble)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.121 ml	10.604 ml	21.208 ml
  5 mM	0.424 ml	2.121 ml	4.242 ml
  10 mM	0.212 ml	1.06 ml	2.121 ml
  50 mM	0.042 ml	0.212 ml	0.424 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 2. [IF=6.057] Ghazala Ashraf et al."Extension of duplex specific nuclease sensing application with RNA aptamer."Talanta. 2022 May;242:123314

• 1. 袁冬冬,王亚蕾,张寒娟,王高彪,郭丽萍,可钰.LC-MS/MS法测定中原汉族房颤患者利伐沙班血浆药物浓度[J].药物分析杂志,2020,40(08):1399-1404.

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *