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• 产品描述： SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.

• 靶点： FGFR;PDGFR;VEGFR

• 体内研究： In mice, SU5416 (25 mg/kg, i.p.) inhibits subcutaneous growth of a panel of tumor cell lines by inhibiting the angiogenic process associated with tumor growth.

• 细胞实验： Tumor cell lines used in the in vitro growth are cultured in media at 37°C in 5–10% CO2. SU5416 is serially diluted in media containing DMSO (<0.5%) and added to cultures of tumor cells 1 day after the initiation of culture. Cell growth is measured after 96 h using the sulforhodamine B method. IC50s are calculated by curve fitting using four-parameter analysis.(Only for Reference)

• 参考文献：
  1.Li Y, et al. Calcif Tissue Int. 2013, 93(6), 556-5 64. 2.Sun L, et al. J Med Chem. 1999, 42(25), 5120-5130. 3.Lo AK, et al. J Pathol. 2015. doi: 10.12002/path.4575. 4.Fong TA, et al. Cancer Res. 1999, 59(1), 99-106. 5.Trzcińska-Daneluti AM, et al. RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. Mol Cell Proteomics. 2015 Jun;14(6):1569-83.

• 溶解性： DMSO:29.6  mg/mL  (100  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.375 ml	16.874 ml	33.747 ml
  5 mM	0.675 ml	3.375 ml	6.749 ml
  10 mM	0.337 ml	1.687 ml	3.375 ml
  50 mM	0.067 ml	0.337 ml	0.675 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *