| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80587-5mg |
98.50% | ￥200.00 | >10 | - | - | - |
|
S80587-10mg |
98.50% | ￥320.00 | 1 | - | - | - |
|
S80587-25mg |
98.50% | ￥630.00 | 6 | - | - | - |
|
S80587-50mg |
98.50% | ￥800.00 | 1 | - | - | - |
|
S80587-100mg |
≥98% | ￥1310.00 | 货期：2-3天 | - | - | - |
|
S80587-200mg |
≥98% | ￥2550.00 | 货期：2-3天 | - | - | - |
|
S80587-250mg |
≥98% | ￥2900.00 | 货期：2-3天 | - | - | - |
|
| 产品描述： | XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | TNKS2:2 nM (IC50);TNKS1:5 nM (IC50);ARTD2:479 nM (IC50)；ARTD1：5500 nM (IC50);PARP;Wnt/beta-catenin | ||||||||||||||||||||
| 体内研究： | XAV-939 rescues mechanical stress-induced cartilage degeneration in vivo | ||||||||||||||||||||
| 参考文献： | 1. Mohit Narwal, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9. 2. Nuha Almasoud, et al. Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Sci Rep. 2020 Oct 7;10(1):16746. 3. Senxin Cai, et al. Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling. Bone. 2022 Aug;161:116445. | ||||||||||||||||||||
| 溶解性： | DMSO : 15.62 mg/mL (50.01 mM; ultrasonic and warming and heat to 60°C) H2O : < 0.1 mg/mL (insoluble) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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