品牌：源叶(MedMol)

产品编号：S80628 一键复制产品信息

CAS号：315183-21-2

分子式：C₂₃H₂₈N₄O₂

分子量：392.49

MDL：MFCD03302441

别名：4-(苯基甲基)-1-哌嗪乙酸 2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼;PAC1(4-(苯基甲基)-1-哌嗪乙酸 2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼);(4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide 1-Piperazineacetic acid; (E)-

货号	规格	价格	上海	北京	珠海	武汉
S80628-5mg	99.30%	￥200.00 S80628-5mg ￥200.00 现货	7 7	-	-	-
S80628-10mg	99.30%	￥370.00 S80628-10mg ￥370.00 现货	10 10	-	-	-
S80628-25mg	99.30%	￥630.00 S80628-25mg ￥630.00 现货	5 5	-	-	-
S80628-50mg	99.30%	￥1020.00 S80628-50mg ￥1020.00 现货	5 5	-	-	-
S80628-100mg	99.30%	￥1870.00 S80628-100mg ￥1870.00 现货	5 5	-	-	-
S80628-200mg	≥98%	￥3230.00 S80628-200mg ￥3230.00 2-3天	0 货期：2-3天	-	-	-
S80628-250mg	≥98%	￥3570.00 S80628-250mg ￥3570.00 2-3天	0 货期：2-3天	-	-	-

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产品描述：

PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC50 of 2.08 μM.

靶点：

Procaspase-3:2.08 μM (EC50);Apoptosis;Caspase;Autophagy

体内研究：

To evaluate the in vivo effect of WF-210 on the growth of malignant tumors, we examined the ability of WF-210 to suppress tumor growth in mouse Hep3B and MDA-MB-435 xenograft models. These two cell lines express procaspase-3 at relatively high levels. Tumors induced by xenografts of the liver cancer cell Hep3B are allowed to develop and grow to a size of 100 mm3, after which WF-210 (2.5 mg/kg) or PAC-1 (5.0 mg/kg) is given daily for two weeks by intravenous (i.v.) administration. As shown in both PAC-1 and WF-210 significantly inhibits the growth of Hep3B tumor xenografts

参考文献：

1. Wang F, et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8(8):1640-52. 2. Seervi M, et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 2013 Dec 19;4:e968. 3. Putt KS, et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50.

溶解性：

DMSO : 50 mg/mL (127.39 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.548 ml	12.739 ml	25.478 ml
5 mM	0.51 ml	2.548 ml	5.096 ml
10 mM	0.255 ml	1.274 ml	2.548 ml
50 mM	0.051 ml	0.255 ml	0.51 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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