S80638 |
Triflusal |
| MedMol | 98% |
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- 产品描述： Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
- 靶点： COX;PDE;PPAR
- 体内研究： Triflusal (10 mg/kg i.v.) reduces platelet deposition on subendothelium-induced primary thrombus by about 68% in rabbits. Triflusal (10 mg/kg i.v.) reduces platelet deposition on a fresh thrombus formed over tunica media by about 48% in rabbits. Triflusal (40 mg/kg p.o.) reduces platelet deposition on a primary thrombus triggered by subendothelium and tunica media by 53% in rabbits. Triflusal (40 mg/kg p.o.) significantly reduces Cox-2 mRNA levels and protein levels without influence Cox-1 mRNA levels on the vascular wall in rabbits. Triflusal (600 mg/day for 5 days) results in an increase in NO production by neutrophils and an increase in endothelial nitric oxide synthase (eNOS) protein expression in neutrophils in healthy volunteers. Triflusal (300 mg, twice-daily orally) shows a more important increase in total walking distance and in pain-free walking distance over the basal values than those treated with placebo, together with an improvement of the symptomatology correlated with claudication in patients with chronic peripheral arteriopathy. Triflusal (300 mg, twice-daily orally) shows an increase in the peak-flow recorded through strain-gauge plethysmography in patients with chronic peripheral arteriopathy. Triflusal (30 mg/kg) strongly decreases iNOS immunolabeling at both survival times analyzed, attenuating iNOS immunoreactivity in astroglial cells and infiltrated neutrophils in rats. Triflusal (30 mg/kg) decreases neuronal and microglial COX-2 expression at 10 and 24 hours after lesion and
- 参考文献：
1. Duran X, et al. J Thromb Haemost, 2008, 6(8), 1385-1392. 2. De Miguel LS, et al. Eur J Clin Invest, 2000, 30(9), 811-817. 3. Auteri A, et al. Int J Clin Pharmacol Res, 1995, 15(2), 57-63. 4. González-Correa JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jan;371(1):81-8. 5. Acarin L, et al. Stroke, 2002, 33(10), 2499-2505.
- 溶解性： Soluble in DMSO、Ethanol
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 4.03 ml 20.148 ml 40.297 ml 5 mM 0.806 ml 4.03 ml 8.059 ml 10 mM 0.403 ml 2.015 ml 4.03 ml 50 mM 0.081 ml 0.403 ml 0.806 ml
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输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
