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• 产品描述： FCCP, a potent uncoupler of oxidative phosphorylation in mitochondria, transport protons across cell membranes leading to disrupts ATP synthesis.

• 靶点： ATPase;Mitochondrial Metabolism

• 体内研究： FCCP significantly reduces mitochondrial membrane potential and ATP production in 8-cell mouse embryos and the number of inner cell mass cells within blastocysts with unchanged blastocyst development. This perturbed embryonic mitochondrial function is concomitant with reduced birth weight in female offspring following embryo transfer, which persists until weaning. Although FCCP-treated males also exhibits reduced glucose tolerance as female, but their insulin sensitivity and adiposity gain between 4 and 14 weeks is unchanged. Reducing mitochondrial function and, thus, decreasing ATP output in the precompacting embryo can influence offspring phenotype

• 细胞实验： Protein synthesis rate is assayed in 24-mm diameter multi-well dishes with fresh medium containing 0.175 Ci/mmol of [3H]methionine (200 μM), for 30 min at 37°C. PC12 cells are treated with FCCP for different period of times. (Only for Reference)

• 参考文献：
  1. Guimarães EL, et al. BMC Gastroenterol. 2012, 12:68. 2.Zander-Fox DL, et al. Biol Reprod. 2015, 92(5):124. 3.Shi J, Zhang F, Chen L, et al. Systemic mitochondrial disruption is a key event in the toxicity of bacterial pore‐forming toxins to Caenorhabditis elegans[J]. Environmental Microbiology. 4.Muñoz F, et al. FEBS Lett. 2001, 492(1-2):156-159.

• 溶解性： DMSO:25.4  mg/mL  (100  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.934 ml	19.672 ml	39.344 ml
  5 mM	0.787 ml	3.934 ml	7.869 ml
  10 mM	0.393 ml	1.967 ml	3.934 ml
  50 mM	0.079 ml	0.393 ml	0.787 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *