货号	规格	价格	上海	北京	珠海	武汉
S80761-5mg	99.00%	￥392.00 S80761-5mg ￥392.00 现货	1 1	-	-	-
S80761-10mg	99.00%	￥720.00 S80761-10mg ￥720.00 现货	5 5	-	-	-
S80761-50mg	99.00%	￥1760.00 S80761-50mg ￥1760.00 现货	5 5	-	-	-
S80761-100mg	99.00%	￥2800.00 S80761-100mg ￥2800.00 现货	4 4	-	-	-

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产品描述：

TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.

靶点：

IKK-2:17.9 nM (IC50);STAT3 ;Apoptosis;IκB/IKK;STAT

体内研究：

TPCA-1 (3, 10, or 20 mg/kg, i.p.) results in a dose-dependent reduction in the severity of murine collagen-induced arthritis (CIA). TPCA-1(10 mg/kg, i.p. daily) inhibits growth of NSCLC with EGFR mutation and potentiates antitumor effect of ZD1839 in xenograft models.

参考文献：

1. Sachse F, et al. IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro.Rhinology. 2011 Jun;49(2):168-73. 2. Podolin PL, et al. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflamm 3. Nan J, et al. TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers. Mol Cancer Ther. 2014 Mar;13(3):617-29.

溶解性：

DMSO : ≥ 100 mg/mL (358.05 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.581 ml	17.903 ml	35.805 ml
5 mM	0.716 ml	3.581 ml	7.161 ml
10 mM	0.358 ml	1.79 ml	3.581 ml
50 mM	0.072 ml	0.358 ml	0.716 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(2篇)

2. [IF=9.6] Jiawen Zou et al."Coaxial 3D Printing of Blood Vessels for Monitoring Monocyte-Endothelium Interactions and Drug Discovery."Advanced Healthcare Materials.2025 Jun;:2404132 1. [IF=18.027] Qi Qiao et al."Hybrid Biomimetic Nanovesicles to Drive High Lung Biodistribution and Prevent Cytokine Storm for ARDS Treatment."ACS Nano.2022;XXXX(XXX):XXX-XXX

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