| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80761-5mg |
99.00% | ￥392.00 | 1 | - | - | - |
|
S80761-10mg |
99.00% | ￥720.00 | 5 | - | - | - |
|
S80761-50mg |
99.00% | ￥1760.00 | 5 | - | - | - |
|
S80761-100mg |
99.00% | ￥2800.00 | 4 | - | - | - |
|
| 产品描述： | TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation. | ||||||||||||||||||||
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| 靶点： | IKK-2:17.9 nM (IC50);STAT3 ;Apoptosis;IκB/IKK;STAT | ||||||||||||||||||||
| 体内研究： | TPCA-1 (3, 10, or 20 mg/kg, i.p.) results in a dose-dependent reduction in the severity of murine collagen-induced arthritis (CIA). TPCA-1(10 mg/kg, i.p. daily) inhibits growth of NSCLC with EGFR mutation and potentiates antitumor effect of ZD1839 in xenograft models. | ||||||||||||||||||||
| 参考文献： | 1. Sachse F, et al. IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro.Rhinology. 2011 Jun;49(2):168-73. 2. Podolin PL, et al. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflamm 3. Nan J, et al. TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers. Mol Cancer Ther. 2014 Mar;13(3):617-29. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 100 mg/mL (358.05 mM) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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