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• 产品描述： Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases

• 靶点： Human Endogenous Metabolite

• 体外研究： Prostaglandin E1 (1 nM-10 μM; 48 h) concentration-dependently reduces HUVECs proliferation (up to 100% inhibition) in the presence of VEGF (20 ng/mL), with an IC50 of 400 nM.
  Prostaglandin E1 (0.01-10 μM; 6 h) inhibits VEGF-induced HUVECs migration in a concentration dependent manner, with an IC50 of 500 nM.
  Prostaglandin E1 (1-5 μM; 12-18 h) inhibits in vitro angiogenesis.
  Prostaglandin E1 (0.01-10 μM; 20 min) increases intracellular cAMP levels in HUVECs.

• 体内研究： Prostaglandin E1 (20 ng/animal/day; s.c. for 4 days) significantly inhibits the FGF-induced angiogenesis in mice. Animal Model: C57/bl6 female mice (6-8 weeks) were injected with Matrigel supplemented with aFGF and heparin Dosage: 20 ng/day/animal Administration: Minipump placed subcutaneously for 4 days Result: Visibly reduced the neovascularization process.

• 参考文献：
  1. Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. 2. Cattaneo MG, et, al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. Br J Pharmacol. 2003 Jan;138(2):377-85. 3. Hauck EW, et, al. Prostaglandin E1 long-term self-injection programme for treatment of erectile dysfunction--a follow-up of at least 5 years. Andrologia. 1999;31 Suppl 1:99-103.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.821 ml	14.105 ml	28.21 ml
  5 mM	0.564 ml	2.821 ml	5.642 ml
  10 mM	0.282 ml	1.411 ml	2.821 ml
  50 mM	0.056 ml	0.282 ml	0.564 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=13.281] Ting Li et al.Engineered Platelet-Based Micro/Nanomotors for Cancer Therapy.Small.2021 Nov 05

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *