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• 产品描述： Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

• 靶点： IL-6;IL-1;STAT3

• 体内研究： At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug

• 参考文献：
  1. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61. 2. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

• 溶解性： Soluble  in  DMSO、1M  NaOH  

• 保存条件： RT,避光

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.799 ml	13.993 ml	27.986 ml
  5 mM	0.56 ml	2.799 ml	5.597 ml
  10 mM	0.28 ml	1.399 ml	2.799 ml
  50 mM	0.056 ml	0.28 ml	0.56 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *