S81172 |
Dapagliflozin ((2S)-1,2-propanediol, hydrate) |
| 源叶(MedMol) | 99% |
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- 产品描述： Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors
- 靶点： SGLT2
- 体外研究： Dapagliflozin is a small-molecule inhibitor of SGLT2 that has been shown to be highly selective for SGLT2 compared with other SGLT family members and to have no off-target interactions in an in vitro screen of more than 330 receptors, enzymes, ion channels, and transporters
- 体内研究： Dapagliflozin demonstrates good oral bioavailability, has a high volume of distribution, and has an in vivo metabolite profile that is qualitatively similar between preclinical species and humans. Both non-clinical and clinical assessments have shown dapagliflozin to have a highly favorable safety profile that is consistent with its simple mechanism of action, with no off-target effects observed
- 动物实验： Animal Models: Sprague-Dawley (SD) rats Dosages: 25, 100, 150, or 200 mg/kg Administration: oral
- 参考文献：
1. Reilly TP, et al. Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus. Diabetes Ther. 2014, 5(1):73-96.
- 溶解性： Soluble in DMSO、Ethanol
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 1.988 ml 9.941 ml 19.881 ml 5 mM 0.398 ml 1.988 ml 3.976 ml 10 mM 0.199 ml 0.994 ml 1.988 ml 50 mM 0.04 ml 0.199 ml 0.398 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
