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• 产品描述： Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation

• 靶点： GCGR

• 体内研究： Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice

• 参考文献：
  1. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81. 2. Hirota K, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003 Apr 11;278(15):13056-60. 3. Song KH, et al. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in humanhepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology. 2006 Jan;43(1):117-25. 4. Capozzi ME, et al. Glucagon lowers glycemia when β-cells are active. JCI Insight. 2019 Jul 23;5. pii: 129954.

• 溶解性： H2O  :  6.67  mg/mL  (1.92  mM;  ultrasonic  and  adjust  pH  to  3  with  HCl)    DMSO  :  2.5  mg/mL  (0.72  mM;  Need  ultrasonic)

• 保存条件： -20℃,避光

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	0.287 ml	1.436 ml	2.871 ml
  5 mM	0.057 ml	0.287 ml	0.574 ml
  10 mM	0.029 ml	0.144 ml	0.287 ml
  50 mM	0.006 ml	0.029 ml	0.057 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 2. [IF=6.2] Hongyuan Cui et al."Ti3C2 MXene-based aptasensor for sensitive and simultaneous detection of two diabetes biomarkers."Surfaces and Interfaces.2023 Oct;41:103196

• 1. [IF=9.083] Jiangwei Xiao et al."Development of an in vitro insulin resistance dissociated model of hepatic steatosis by co-culture system."BioScience Trends

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *