品牌：源叶(MedMol)

产品编号：S81428 一键复制产品信息

CAS号：20324-87-2

分子式：C₂₁H₁₄N₂Na₂O₉S₂

分子量：548.45

别名：猩红酸钠盐;6,6'-(1,3-亚脲基)双(1-萘酚-3-磺酸钠);猩红酸钠;7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt;Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate);Sodium 6,6'-(

货号	规格	价格	上海	北京	珠海	武汉
S81428-2mg	99.70%	￥119.00 S81428-2mg ￥119.00 现货	9 9	-	-	-
S81428-5mg	99.70%	￥178.00 S81428-5mg ￥178.00 现货	10 10	-	-	-
S81428-10mg	99.70%	￥220.00 S81428-10mg ￥220.00 现货	7 7	-	-	-
S81428-25mg	99.70%	￥370.00 S81428-25mg ￥370.00 现货	9 9	-	-	-
S81428-50mg	99.70%	￥630.00 S81428-50mg ￥630.00 现货	6 6	-	-	-
S81428-100mg	99.70%	￥1080.00 S81428-100mg ￥1080.00 现货	3 3	-	-	-

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产品描述：

AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding

靶点：

IC50: 8.8 μM (PRMT1), 3.0 μM (yeast-Hmt1p);HistoneMethyltransferase

体内研究：

AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo. AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model. AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model

参考文献：

1. Zhang, B., et al. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget. 2015 Sep 8;6(26):22799-811. 2. Baolai Zhang, et al. Arginine Methyltransferase inhibitor-1 Inhibits Sarcoma Viability in vitro and in vivo. Oncol Lett. 2018 Aug;16(2):2161-2166. 3. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9.

溶解性：

H2O : 62.5 mg/mL (113.96 mM; ultrasonic and warming and heat to 60°C)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.823 ml	9.117 ml	18.233 ml
5 mM	0.365 ml	1.823 ml	3.647 ml
10 mM	0.182 ml	0.912 ml	1.823 ml
50 mM	0.036 ml	0.182 ml	0.365 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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