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• 产品描述： ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.

• 靶点： Beta Amyloid

• 体外研究： ARN2966 reduces levels of APP and its intracellular C-terminal fragments α-CTF and β-CTF in CHO APP751SW cells when used at a concentration of 10 μM. ARN2966?also reduces?secretion of Aβ (1-40) and Aβ (1-42) by 88.6 and 84.9%, respectively.

• 体内研究： In vivo,ARN2966? reduces brain levels of full-length APP, α-CTF and β-CTF, and soluble Aβ (1-40) and Aβ (1-42) in the APPSWPS1dE9 transgenic mouse model of Alzheimer's disease.It also improves novel object memory as well as spatial memory in the radial arm maze in APPSWPS1dE9 transgenic mice.

• 参考文献：
  1. Asuni A A . Modulation of APP Expression Reduces Aβ Deposition in a Mouse Model.[J]. Annals of Neurology, 2014, 75(5):684.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	4.994 ml	24.97 ml	49.941 ml
  5 mM	0.999 ml	4.994 ml	9.988 ml
  10 mM	0.499 ml	2.497 ml	4.994 ml
  50 mM	0.1 ml	0.499 ml	0.999 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *