货号	规格	价格	上海	北京	珠海	武汉
S82114-1mg促销	≥98%	￥1000.00 ￥900.00 S82114-1mg ￥900.00 现货	4 4	-	-	-
S82114-5mg促销	≥98%	￥2450.00 ￥2200.00 S82114-5mg ￥2200.00 现货	1 1	-	-	-
S82114-10mg促销	≥98%	￥7340.00 ￥6600.00 S82114-10mg ￥6600.00 现货	2 2	-	-	-

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产品描述：

Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research

靶点：

IC50: 0.1 nM (MX-1 cells), 1.5 nM (MCF7 cells) and 3.7 nM (MCF7/DXR cells) Reactive oxygen species (ROS) Apoptosis;Apoptosis; ReactiveOxygenSpecies

体内研究：

Trabectedin (ET-743; 30-50 μg/kg; intravenous injection; every three days; female athymic nude mice) treatment increases the antitumor effects in nude mice bearing MX-1 mammary carcinoma xenografts without increasing toxicity. A xenograft mouse model of human myxoid liposarcoma (MLS) shows marked reduction of CCL2, CXCL8, CD68+ infiltrating macrophages, CD31+ tumor vessels, and partial decrease of PTX3 after Trabectedin treatment[

参考文献：

1. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15. 2. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136. 3. Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.313 ml	6.563 ml	13.126 ml
5 mM	0.263 ml	1.313 ml	2.625 ml
10 mM	0.131 ml	0.656 ml	1.313 ml
50 mM	0.026 ml	0.131 ml	0.263 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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ecteinascidin 743