S82119 |
6-Cyano-7-Nitroquinoxaline-2,3-Dione |
| 源叶(MedMol) | 98% |
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- 产品描述： CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats
- 靶点： IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)
- 体内研究： CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments
- 参考文献：
1.T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5;241(4866):701-3. 2. Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23;92(1):64-8. 3. Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506(2):297-302. 4. Pia Bäckström, et al. Attenuation of Cocaine-Seeking Behaviour by the AMPA/kainate Receptor Antagonist CNQX in Rats. Psychopharmacology (Berl). 2003 Feb;166(1):69-76. 5. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8
- 溶解性： DMSO : 20 mg/mL (86.15 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
- 保存条件： RT
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 4.308 ml 21.538 ml 43.076 ml 5 mM 0.862 ml 4.308 ml 8.615 ml 10 mM 0.431 ml 2.154 ml 4.308 ml 50 mM 0.086 ml 0.431 ml 0.862 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
