S82906 |
INCB8761(PF-4136309) |
| 源叶(MedMol) | 99% |
- 提示：详情请下载说明书。
- 产品描述： PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
- 靶点： Human CCR2:5.2 nM (IC50);Mouse CCR2:13 nM (IC50);Rat CCR2:17 nM (IC50)
- 体内研究： PF-4136309 (2 mg/kg) exhibits a moderate half-life in both species after iv administration (2.5 and 2.4 h). When administered orally, PF-4136309 (10 mg/kg) is absorbed rapidly, with peak concentration time (Tmax) at 1.2 h for rats and 0.25 h for dogs. A similar half-life is observed in both species between iv dosing and po dosing. PF-4136309 is well absorbed, with an oral bioavailability of 78% in both species
- 参考文献：
1. Xue CB, et al. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918.
- 溶解性： Soluble in DMSO、Ethanol
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 1.759 ml 8.794 ml 17.587 ml 5 mM 0.352 ml 1.759 ml 3.517 ml 10 mM 0.176 ml 0.879 ml 1.759 ml 50 mM 0.035 ml 0.176 ml 0.352 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
