S82970 |
HG-14-10-04 |
| 源叶(MedMol) | 98% |
- 提示：详情请下载说明书。
- 产品描述： HG-14-10-04 is a potent ALK and mutant EGFR inhibitor with IC50s of 20 nM, 15.6 nM, 22.6 nM and 124.5 nM for ALK, EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS, respectively. HG-14-10-04 can be used to research anticancer
- 靶点： EGFRLR/TM：15.6 nM (IC50)；EGFR19del/TM/CS：22.6 nM (IC50)；EGFRLR/TM/CS：124.5 nM (IC50)；ALK：20 nM (IC50)
- 体外研究： HG-14-10-04 (example 10) has inhibitory activity against ALK kinase with an IC50 of 20 nM HG-14-10-04 (compound 17b) exhibits kinase inhibitory activity against EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS with IC50s of 15.6 nM, 22.6 nM and 124.5 nM, respectively
- 参考文献：
1. U.S. Pat. Appl. Publ. (2012), US 20120028924 A1 2. Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858.
- 溶解性： Soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 1.879 ml 9.397 ml 18.794 ml 5 mM 0.376 ml 1.879 ml 3.759 ml 10 mM 0.188 ml 0.94 ml 1.879 ml 50 mM 0.038 ml 0.188 ml 0.376 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
