货号	规格	价格	上海	北京	珠海	武汉
S83021-1mg	99.70%	￥300.00 S83021-1mg ￥300.00 现货	4 4	-	-	-
S83021-5mg	99.70%	￥750.00 S83021-5mg ￥750.00 现货	7 7	-	-	-
S83021-10mg	99.70%	￥1160.00 S83021-10mg ￥1160.00 现货	13 >10	-	-	-
S83021-25mg	99.70%	￥2140.00 S83021-25mg ￥2140.00 现货	10 10	-	-	-
S83021-50mg	99.70%	￥3400.00 S83021-50mg ￥3400.00 现货	10 10	-	-	-

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产品描述：

Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.

靶点：

EC50: 4 nM (HCV 1a), 3 nM (HCV 1b), 3 nM (HCV 2a);HCVProtease

体外研究：

Elbasvir shows potent activity against genotype 1a and 1b replicons, with EC90 of 0.006 nM for both the wild-type 1a_H77 and 1b_con1 replicons. Elbasvir inhibits genotype 3 replicons with EC90 of 0.12 nM. Elbasvir (0.06 nM, 0.6 nM, and 6 nM) demonstrates dose-dependent suppression of resistant genotype 1a replicons, illustrated by the reductions in colony counts at higher doses. Elbasvir is highly potent against HCV replicons bearing NS5A sequences from GT1a, -1b, -2a(31L), -3a, -4a, -5a, and -6, with EC50s in the low-picomolar range

参考文献：

1. Liu R, et al. Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor Elbasvir. Antimicrob Agents Chemother. 2015 Nov;59(11):6922-6929. 2. Lahser FC, et al. The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons. Antimicrob Agents Chemother. 2016 A

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.134 ml	5.669 ml	11.338 ml
5 mM	0.227 ml	1.134 ml	2.268 ml
10 mM	0.113 ml	0.567 ml	1.134 ml
50 mM	0.023 ml	0.113 ml	0.227 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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