| 产品描述: | Dihexa is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV. |
| 靶点: |
c-Met/HGFR |
| 体内研究: |
Dihexa (2 mg/kg, i.p.) completely reverses scopolamine-induced learning deficits in the latency to find the platform and increases the time spent in the target quadrant in the Morris water maze in rats |
| 参考文献: |
1. Mccoy A T , Benoist C C , Wright J W , et al. Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents[J]. Journal of Pharmacology and Experimental Therapeutics, 2013, 344(1):141-154. 2. Benoist C C , Kawas L H , Zhu M , et al. The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System[J]. Journal of Pharmacology and Experimental Therapeutics, 2014, 351(2):390-402. |
| 溶解性: |
soluble in DMSO |
| 保存条件: |
-20℃ |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
1.982 ml |
9.908 ml |
19.815 ml |
| 5 mM |
0.396 ml |
1.982 ml |
3.963 ml |
| 10 mM |
0.198 ml |
0.991 ml |
1.982 ml |
| 50 mM |
0.04 ml |
0.198 ml |
0.396 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |