- 提示：详情请下载说明书。
- 产品描述： HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1
- 靶点： IC50: 0.67 μM (PCA-1)
- 体外研究： HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells
- 体内研究： HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model. HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration. Animal Model: Nude mice Dosage: 32 mg/kg Administration: Subcutaneous injection; daily; 6 days Result: Has inhibitory effect on the growth of subcutaneously implanted DU145, without limiting weight gains after a 6 days continuous administration.
- 参考文献：
1. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4.
- 溶解性： soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 3.141 ml 15.705 ml 31.41 ml 5 mM 0.628 ml 3.141 ml 6.282 ml 10 mM 0.314 ml 1.57 ml 3.141 ml 50 mM 0.063 ml 0.314 ml 0.628 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
