S83420 |
BM212 |
| 源叶(MedMol) | 99% |
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- 产品描述： BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM
- 靶点： M. tuberculosis
- 体外研究： BM212 (2 μg/mL and 8 μg/mL) leads to major structural changes in the cell of M. abscessus CIP104536T S and R variants and results in the complete loss of the hydrophobic nanodomains observed on S cells but no significantly affect on R cells at dose of 2 μg/mL. BM212 (0.5-10 μg/mL, 7 days) inhibits the activity of Mycobacterium avium in U937 cells in a dose-dependent manner with a MIC of 0.5 μg/mL and 100% inhibition starting at a concentration of 1 μg/mL
- 参考文献：
1. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. 2. Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) 3. Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5(6):944-953. 4. Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7.
- 溶解性： Soluble in DMSO、Ethanol
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.413 ml 12.066 ml 24.133 ml 5 mM 0.483 ml 2.413 ml 4.827 ml 10 mM 0.241 ml 1.207 ml 2.413 ml 50 mM 0.048 ml 0.241 ml 0.483 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
