S83917 |
6-FORMYLINDOLO [3,2-B] CARBAZOLE |
| 源叶(MedMol) | 95% |
![6-FORMYLINDOLO [3,2-B] CARBAZOLE](images/info/380005.png)
- 提示：详情请下载说明书。
- 产品描述： FICZ (6-Formylindolo[3,2-b]carbazole) 是一种 aryl hydrocarbon receptor (AhR) 的有效激动剂，可被AHR调节的细胞色素P4501酶有效地代谢
- 靶点： AhR
- 体内研究： FICZ improves the atopic dermatitis-like skin inflammation, clinical scores, and transepidermal water loss in NC/Nga mice compared with those of control mice. On histology, FICZ significantly reduces the epidermal and dermal thickness as well as the number of mast cells. Topical FICZ also significantly reduces the gene expression of Il22.
- 细胞实验： Cell lines: Human immortalized HaCaT cells, normal human epidermal keratinocytes (NHEKs) Concentrations: 1 nM, 10 nM, 100 nM Incubation Time: 1 h, 3 h, 5 h Method: HaCaTcells or NHEKs (1×104 cells/well) are platedon an 8-well μ-slide for 48 h, and treated with or without FICZ for 3 or 1 h, respectively. Then, the cells are washed with phosphate-buffered saline (PBS), fixed with acetone for 10 min, and blocked with 5% (w/v) bovine serum albumin in PBS for 30 min. The cells are then incubated with primary rabbit anti-AHR antibody (1:100) overnight at 4 ℃. Specific binding is detected using a horseradish peroxidase-conjugated goat anti-rabbit anti-body followed by tyramide labeling with green-fluorescent Alexa Fluor 488 for 1 h at room temperature in accordance with the manufacturer's instructions.
- 动物实验： Animal Models: 9–10 week-old female NC/Nga mice Dosages: 100 mg/affected area Administration: Topical
- 参考文献：
1. Emma Wincent, et al. Biochem Pharmacol. 2016 Jun 15;110-111:117-29. 2. Mari Kiyomatsu-Oda, et al. J Dermatol Sci. 2018 Jun;90(3):284-294.
- 溶解性： Soluble in DMSO
- 保存条件： 2-8℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 3.517 ml 17.586 ml 35.173 ml 5 mM 0.703 ml 3.517 ml 7.035 ml 10 mM 0.352 ml 1.759 ml 3.517 ml 50 mM 0.07 ml 0.352 ml 0.703 ml
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