S84063 |
Tipiracil |
源叶(MedMol) | 99% |
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- 产品描述: Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
- 靶点: thymidine phosphorylase
- 体外研究: Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment for metastatic colorectal cancer. Tipiracil prevents degradation of FTD through a first-pass effect as a thymidine phosphorylase inhibitor
- 参考文献:
1. Lee SJ, et al. Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1327-35. 2. Raedler LA. Lonsurf (Trifluridine plus Tipiracil): A New Oral Treatment Approved for Patients with Metastatic Colorectal Cancer. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):97-100. 3. Tanaka N, et al. Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models. Oncol Rep. 2014 Dec;32(6):2319-26.
- 溶解性: Soluble in H2O
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 4.121 ml 20.605 ml 41.21 ml 5 mM 0.824 ml 4.121 ml 8.242 ml 10 mM 0.412 ml 2.06 ml 4.121 ml 50 mM 0.082 ml 0.412 ml 0.824 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)