| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S84211-1mg |
97.80% | ￥700.00 | >10 | - | - | - |
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S84211-5mg |
97.80% | ￥1780.00 | >10 | - | - | - |
|
S84211-10mg |
97.80% | ￥2850.00 | >10 | - | - | - |
|
S84211-25mg |
97.80% | ￥4070.00 | >10 | - | - | - |
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| 产品描述： | AP20187 (B/B Homodimerizer, HY-13992) 是一种二聚化的化学诱导剂，可激活 FKBP-Casp8 | ||||||||||||||||||||
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| 靶点： | FKBP; Casp8;Others | ||||||||||||||||||||
| 体外研究： | In oligodendrocytes, AP20187 treatment increases the expression of PERK-responsive genes encoding CAATT enhancer binding protein homologous protein (CHOP) and growth arrest and DNA damage 34 (GADD34) in a dose-dependent manner. The activity of PERK signaling in oligodendrocytes can be temporally manipulated by the administration of AP20187 | ||||||||||||||||||||
| 体内研究： | AP20187 treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mice. AP20187 is also sufficient to activate Fv2E-PERK in oligodendrocytes in the CNS of PLP/Fv2E-PERK mice. | ||||||||||||||||||||
| 细胞实验： | Cell lines: Oligodendrocytes Concentrations: 1 nM Incubation Time: 4 h Method: After 3 d of differentiation, the cells are treated with 1 nM AP20187 or vehicle for 4 h and are then fixed with cold 4% paraformaldehyde in PBS. The cells are blocked with PBS containing 10% goat serum and 0.1% Triton X-100 and incubate overnight with the primary antibody diluted in blocking solution. Appropriate fluorochrome-labeled secondary antibodies are used for detection. | ||||||||||||||||||||
| 动物实验： | Animal Models: PLP/Fv2E-PERK mice Dosages: 0.5 mg/kg, 2 mg/kg, 5 mg/kg Administration: i.p. | ||||||||||||||||||||
| 参考文献： | 1. Darren J Baker, et al. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature . 2016 Feb 11;530(7589):184-9. 2. Wensheng Lin, et al. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci . 2013 Apr 3;33(14):5980-91. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京