S84219 |
Atrasentan hydrochloride (ABT-627 hydrochloride) |
| 源叶(MedMol) | 99% |
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- 产品描述： Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC50 of 0.0551 nM for ETA
- 靶点： IC50: 0.055 nM (ETA)
- 体内研究： Atrasentan hydrochloride (ABT-627 hydrochloride) (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats. Aatrasentan (ABT-627, 10 mg/kg, i.p.) inhibits the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model
- 参考文献：
1. Yuyama H, et al. Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. Eur J Pharmacol. 2004 Sep 13;498(1-3):171-7. 2. Banerjee S, et al. In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 combination in prostate cancer. Cancer Res. 2007 Apr 15;67(8):3818-26. 3. Weiss J, et al. Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro. Cancer Chemother Pharmacol. 2011 Oct;68(4):1093-8.
- 溶解性： DMSO : 28.57 mg/mL (52.22 mM; Need ultrasonic) H2O : 0.5 mg/mL (0.91 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C) 0.1 M HCL : < 1 mg/mL (ultrasonic;warming;adjust pH to 1 with HCl;heat to 60°C) (insoluble)
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 1.828 ml 9.139 ml 18.279 ml 5 mM 0.366 ml 1.828 ml 3.656 ml 10 mM 0.183 ml 0.914 ml 1.828 ml 50 mM 0.037 ml 0.183 ml 0.366 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
