品牌：源叶(MedMol)

产品编号：S84279 一键复制产品信息

CAS号：201341-05-1

分子式：C₁₉H₃₀N₅O₁₀P

分子量：519.44

别名：替诺福韦酯;(R)-9-(2-磷酸甲氧基丙基)腺嘌呤二(异丙氧羰基氧甲基)酯;替诺福韦酯(富马酸盐);替诺福韦二吡呋酯;5-[[(1r)-2-(6-Amino-9h-Purin-9-Yl)-1-Methylethoxy]Methyl]-2,4,6,8-Tetraoxa-5-Phosphanononanedioic Acid Bis(1-Methylethyl) Ester 5-Oxide;9-((

货号	规格	价格	上海	北京	珠海	武汉
S84279-10mg	99.90%	￥190.00 S84279-10mg ￥190.00 现货	4608 >10	-	-	-
S84279-50mg	99.90%	￥430.00 S84279-50mg ￥430.00 现货	928 >10	-	-	-
S84279-100mg	99.90%	￥610.00 S84279-100mg ￥610.00 现货	468 >10	-	-	-
S84279-500mg	99.90%	￥1440.00 S84279-500mg ￥1440.00 现货	100 >10	-	-	-

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产品描述：

Tenofovir Disoproxil (Bis(POC)-PMPA) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.

靶点：

HIV-1;HBV; HIVProtease; ReverseTranscriptase

体内研究：

Tenofovir Disoproxil Fumarate (20, 50, 140, or 300 mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300 mg/kg) significantly reduces HIV transmission in BLT mice. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection

参考文献：

1. Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3) 2. Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018 3. Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098 4. Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8.

溶解性：

DMSO : ≥ 38 mg/mL (73.16 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.925 ml	9.626 ml	19.252 ml
5 mM	0.385 ml	1.925 ml	3.85 ml
10 mM	0.193 ml	0.963 ml	1.925 ml
50 mM	0.039 ml	0.193 ml	0.385 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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Tenofovir disoproxil