S84409 |
Purvalanol B ( NG 95) |
| 源叶(MedMol) | 96% |
- 提示：详情请下载说明书。
- 产品描述： Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum
- 靶点： cdc2/cyclin B:6 nM (IC50);cdk2/cyclin A:6 nM (IC50);CDK2/cyclinE:9 nM (IC50);CDK5/p35:6 nM (IC50)
- 参考文献：
1. Gray NS, et, al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. 2. Bullard KM, et, al. Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites. Malar J. 2015 Apr 8;14:147.
- 溶解性： Soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.31 ml 11.55 ml 23.1 ml 5 mM 0.462 ml 2.31 ml 4.62 ml 10 mM 0.231 ml 1.155 ml 2.31 ml 50 mM 0.046 ml 0.231 ml 0.462 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
