货号	规格	价格	上海	北京	珠海	武汉
S84534-1mg	98.10%	￥196.00 S84534-1mg ￥196.00 现货	5 5	-	-	-
S84534-2mg	98.10%	￥340.00 S84534-2mg ￥340.00 现货	5 5	-	-	-
S84534-5mg	98.10%	￥598.00 S84534-5mg ￥598.00 现货	6 0 6	-	-	-
S84534-10mg	98.10%	￥938.00 S84534-10mg ￥938.00 现货	5 5	-	-	-
S84534-25mg	98.10%	￥1700.00 S84534-25mg ￥1700.00 现货	3 3	-	-	-
S84534-50mg	≥98%	￥2770.00 S84534-50mg ￥2770.00 2-3天	0 货期：2-3天	-	-	-
S84534-100mg	≥98%	￥3900.00 S84534-100mg ￥3900.00 2-3天	0 货期：2-3天	-	-	-

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产品描述：

Emapunil (AC-5216), an orally active and selective TSPO (a mitochondrial benzodiazepine receptor) ligand, produces anti-anxiety and antidepressant-like effects in various animal models

靶点：

Others

体内研究：

Emapunil (AC-5216, 0.1-3, 0.003-0.01 and 0.01-0.3 mg/kg, p.o.) produces anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice. Emapunil (AC-5216, 3-30 mg/kg, p.o.) reduces the immobility time, and this effect was blocked by PK11195. Emapunil (AC-5216, 1-100 mg/kg, p.o.) produces no distinct change in the rat electroencephalogram. Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) causes significant suppression of the enhanced anxiety and contextual fear induced in post-TDS rats. Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) alleviates the enhanced anxiety and fear response in a time-dependent sensitization (TDS) procedure, a rat PTSD animal model. Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) reverses the increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats

参考文献：

1. Atsuko Kita, et al. Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br J Pharmacol. 2004 Aug;142(7):1059-72. 2. Marcus Karlstetter, et al. Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014 Jan 8;11:3. 3. Li-Ming Zhang, et al. Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216. J Psychopharmacol. 2016 May;30(5):474-81. 4. Zhi-Kun Qiu, et al. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus. Sci Rep. 2016 Nov 25;6:37345.

溶解性：

DMSO : 33.33 mg/mL (83.02 mM; Need ultrasonic)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.491 ml	12.454 ml	24.909 ml
5 mM	0.498 ml	2.491 ml	4.982 ml
10 mM	0.249 ml	1.245 ml	2.491 ml
50 mM	0.05 ml	0.249 ml	0.498 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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