货号	规格	价格	上海	北京	珠海	武汉
S84602-5mg	99.60%	￥240.00 S84602-5mg ￥240.00 现货	9 9	-	-	-
S84602-10mg	99.60%	￥450.00 S84602-10mg ￥450.00 现货	8 8	-	-	-
S84602-50mg促销	99.60%	￥1700.00 ￥1360.00 S84602-50mg ￥1360.00 现货	7 7	-	-	-
S84602-100mg促销	≥98%	￥2900.00 ￥2320.00 S84602-100mg ￥2320.00 2-3天	0 货期：2-3天	-	-	-

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产品描述：

TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC5050

靶点：

CYP1B1:6 nM (IC50);CYP1A1:300 nM (IC50);CYP1A2:3.1 μM (IC50);CYP1B1:3 nM (Ki);P450

体内研究：

To determine the contribution of CYP1B1 in development of hypertension in spontaneously hypertensive rats (SHR), the effect of TMS is examined on in SHR and WKY rats. Systolic BP steadily increases in SHR from 4 weeks of age. Starting from 8 weeks of age, daily injections of TMS reduce systolic BP in SHR to levels observed at the beginning of the experiment (207±7 vs. 129±2 mmHg). Systolic BP is not altered in WKY injected with TMS or its vehicle (129±7 vs. 127±4 mmHg)

参考文献：

1. Sanghee Kim, et al. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4. 2. Einem Lindeman T, et al. The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. Mutagenesis. 2011 Sep;26(5):629-35. 3. Jennings BL, et al. Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats. Cardiovasc Drugs Ther. 2014 Apr;28(2):145-61.

溶解性：

DMSO : ≥ 50 mg/mL (166.47 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.329 ml	16.647 ml	33.294 ml
5 mM	0.666 ml	3.329 ml	6.659 ml
10 mM	0.333 ml	1.665 ml	3.329 ml
50 mM	0.067 ml	0.333 ml	0.666 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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